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Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection

Cited 31 time in Web of Science Cited 39 time in Scopus
Authors

Park, S. W.; Perera, R. A. P. M.; Choe, P. G.; Lau, E. H. Y.; Choi, S. J.; Chun, J. Y.; Oh, H. S.; Song, K.; Bang, J. H.; Kim, E. S.; Kim, H. B.; Park, W. B.; Kim, N. J.; Poon, L. L. M.; Peiris, M.; Oh, M.

Issue Date
2015-10
Publisher
Centre Europeen pour la Surveillance Epidemiologique du SIDA
Citation
Eurosurveillance, Vol.20 No.41, pp.30042-17
Abstract
Plaque reduction neutralisation tests (PRNT), micro-neutralisation (MN), Middle East respiratory syndrome (MERS)-spike pseudoparticle neutralisation (ppNT) and MERS S1-enzyme-linked immunosorbent assay (ELISA) antibody titres were compared using 95 sera from 17 patients with MERS, collected two to 46 days after symptom onset. Neutralisation tests correlated well with each other and moderately well with S1 ELISA. Moreover to compare antigenic similarity of genetically diverse MERS-CoV clades, the response of four sera from two patients sampled at two time periods during the course of illness were tested by 90% PRNT. Genetically diverse MERS-CoV clades were anti-genically homogenous.
ISSN
1025-496X
URI
https://hdl.handle.net/10371/199705
DOI
https://doi.org/10.2807/1560-7917.ES.2015.20.41.30042
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  • College of Medicine
  • Department of Medicine
Research Area Immunology, Infectious Diseases, Vaccination, 감염병, 바이러스질환, 예방접종

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