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agr Dysfunction affects staphylococcal cassette chromosome mec type-dependent clinical outcomes in methicillin-resistant staphylococcus aureus bacteremia
DC Field | Value | Language |
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dc.contributor.author | Kang, Chang Kyung | - |
dc.contributor.author | Cho, Jeong Eun | - |
dc.contributor.author | Choi, Yoon Jeong | - |
dc.contributor.author | Jung, Younghee | - |
dc.contributor.author | Kim, Nak-Hyun | - |
dc.contributor.author | Kim, Chung-Jong | - |
dc.contributor.author | Kim, Taek Soo | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Bang, Ji-Hwan | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Park, Sang Won | - |
dc.contributor.author | Kim, Nam-Joong | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.date.accessioned | 2024-04-26T01:06:45Z | - |
dc.date.available | 2024-04-26T01:06:45Z | - |
dc.date.created | 2018-09-19 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | Antimicrobial Agents and Chemotherapy, Vol.59 No.6, pp.3125-3132 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199709 | - |
dc.description.abstract | Staphylococcal cassette chromosome mec element (SCCmec) type-dependent clinical outcomes may vary due to geographical variation in the presence of virulence determinants. We compared the microbiological factors and mortality attributed to methicillin-resistant Staphylococcus aureus (MRSA) bacteremia between SCCmec types II/III and type IV. All episodes of MRSA bacteremia in a tertiary-care hospital (South Korea) over a 4.5-year period were reviewed. We studied the microbiological factors associated with all blood MRSA isolates, including spa type, agr type, agr dysfunction, and the genes for Panton-Valentine leukocidin (PVL) and phenol-soluble modulin (PSM)-mec, in addition to SCCmec type. Of 195 cases, 137 involved SCCmec types II/III, and 58 involved type IV. The mortality attributed to MRSA bacteremia was less frequent among the SCCmec type IV (5/58) than that among types II/III (39/137, P = 0.002). This difference remained significant when adjusted for clinical factors (adjusted odds ratio [aOR], 0.14; 95% confidence interval [CI], 0.04 to 0.49; P = 0.002). Of the microbiological factors tested, agr dysfunction was the only significant factor that showed different positivity between the SCCmec types, and it was independently associated with MRSA bacteremia-attributed mortality (aOR, 4.71; 95% CI, 1.72 to 12.92; P = 0.003). SCCmec type IV is associated with lower MRSA bacteremia-attributed mortality than are types II/III, which might be explained by the high rate of agr dysfunction in SCCmec types II/III in South Korea. | - |
dc.language | 영어 | - |
dc.publisher | American Society for Microbiology | - |
dc.title | agr Dysfunction affects staphylococcal cassette chromosome mec type-dependent clinical outcomes in methicillin-resistant staphylococcus aureus bacteremia | - |
dc.type | Article | - |
dc.identifier.doi | 10.1128/AAC.04962-14 | - |
dc.citation.journaltitle | Antimicrobial Agents and Chemotherapy | - |
dc.identifier.wosid | 000358623200020 | - |
dc.identifier.scopusid | 2-s2.0-84982163107 | - |
dc.citation.endpage | 3132 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 3125 | - |
dc.citation.volume | 59 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Kim, Eu Suk | - |
dc.contributor.affiliatedAuthor | Park, Kyoung Un | - |
dc.contributor.affiliatedAuthor | Park, Sang Won | - |
dc.contributor.affiliatedAuthor | Kim, Nam-Joong | - |
dc.contributor.affiliatedAuthor | Oh, Myoung-don | - |
dc.contributor.affiliatedAuthor | Kim, Hong Bin | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MINIMUM INHIBITORY CONCENTRATION | - |
dc.subject.keywordPlus | BLOOD-STREAM INFECTION | - |
dc.subject.keywordPlus | COMMUNITY-ASSOCIATED MRSA | - |
dc.subject.keywordPlus | SCCMEC TYPE | - |
dc.subject.keywordPlus | VANCOMYCIN | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | STRAINS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | KOREA | - |
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