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Clinical characteristics and risk factors of pyogenic spondylitis caused by gram-negative bacteria
DC Field | Value | Language |
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dc.contributor.author | Kang, Seung-Ji | - |
dc.contributor.author | Jang, Hee-Chang | - |
dc.contributor.author | Jung, Sook-In | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Chung-Jong | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.contributor.author | Oh, Myoung-Don | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Park, Kyung-Hwa | - |
dc.date.accessioned | 2024-04-26T01:06:49Z | - |
dc.date.available | 2024-04-26T01:06:49Z | - |
dc.date.created | 2018-09-10 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | PLoS ONE, Vol.10 No.5, p. e0127126 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199710 | - |
dc.description.abstract | Background There are limited data describing the clinical characteristics of pyogenic spondylitis caused by Gram-negative bacteria (GNB). The aim of this study was to investigate the predisposing factors and clinical characteristics of pyogenic spondylitis caused by GNB compared to Gram-positive cocci (GPC). Methods We performed a retrospective review of medical records from patients with culture-confirmed pyogenic spondylitis at four tertiary teaching hospitals over an 8-year period. Results A total of 344 patients with culture-confirmed pyogenic spondylitis were evaluated. There were 62 patients (18.0%) with pyogenic spondylitis caused by GNB and the most common organism was Escherichia coli (n = 35, 10.2%), followed by Pseudomonas aeruginosa (n = 10, 2.9%). Pyogenic spondylitis caused by GNB was more frequently associated with the female gender (64.5 vs. 35.5%, P < 0.01), preexisting or synchronous genitourinary tract infection (32.3 vs. 2.1%, P < 0.01), and intra-abdominal infection (12.9 vs. 0.4%, P < 0.01) compared to patients with GPC. Although pyogenic spondylitis caused by GNB presented with severe sepsis more frequently (24.2 vs. 11.3%, P = 0.01), the mortality rate (6.0 vs. 5.2%) and the proportion of patients with residual disability (6.0 vs. 9.0%), defined as grade 3 or 4 (P = 0.78) 3 months after completion of treatment, were not significantly different compared to GPC patients. Conclusion GNB should be considered as the etiologic organism when infectious spondylitis develops in a patient with preexisting or synchronous genitourinary tract and intra-abdominal infection. In addition, the mortality rate and clinical outcomes are not significantly different between pyogenic spondylitis caused by GNB and GPC. | - |
dc.language | 영어 | - |
dc.publisher | Public Library of Science | - |
dc.title | Clinical characteristics and risk factors of pyogenic spondylitis caused by gram-negative bacteria | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0127126 | - |
dc.citation.journaltitle | PLoS ONE | - |
dc.identifier.wosid | 000354916100130 | - |
dc.identifier.scopusid | 2-s2.0-84929313672 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | e0127126 | - |
dc.citation.volume | 10 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Kim, Hong Bin | - |
dc.contributor.affiliatedAuthor | Oh, Myoung-Don | - |
dc.contributor.affiliatedAuthor | Kim, Nam Joong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HEMATOGENOUS VERTEBRAL OSTEOMYELITIS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | OUTCOMES | - |
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