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Diagnostic value of direct fluorescence antibody staining for detecting Pneumocystis jirovecii in expectorated sputum from patients with HIV infection

Cited 15 time in Web of Science Cited 19 time in Scopus
Authors

Choe, Pyoeng Gyun; Kang, Yoo Min; Kim, Gayeon; Park, Wan Beom; Park, Sang Won; Kim, Hong Bin; Oh, Myoung-don; Kim, Eui Chong; Kim, Nam Joong

Issue Date
2014-04
Publisher
Taylor & Francis
Citation
Medical Mycology, Vol.52 No.3, pp.326-330
Abstract
Direct fluorescent antibody (DFA) staining of induced sputum is frequently used to diagnose Pneumocystis pneumonia (PCP) in patients infected with human immunodeficiency virus, although induction can provoke nausea and bronchospasm. Since the diagnostic value of expectorated sputum examined with DFA stain has not been well evaluated, we reviewed the medical records of HIV-infected patients who were clinically diagnosed as having PCP between 1999 and 2011. Over this 13-year period, we found 76 patients whose records included the results of DFA staining of expectorated sputum and noted that 42 (55.3%) were positive. Polymerase chain reaction to detect Pneumocystis in the sputum of 65 of the patients resulted in the finding of 43 (66.2%) who were positive. Our findings suggest that DFA staining of expectorated sputum could be a useful initial diagnostic method in HIV-infected patients with PCP.
ISSN
1369-3786
URI
https://hdl.handle.net/10371/199716
DOI
https://doi.org/10.1093/mmy/myu002
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  • College of Medicine
  • Department of Medicine
Research Area Immunology, Infectious Diseases, Vaccination, 감염병, 바이러스질환, 예방접종

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