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Area under the concentration-time curve to minimum inhibitory concentration ratio as a predictor of vancomycin treatment outcome in methicillin-resistant Staphylococcus aureus bacteraemia
DC Field | Value | Language |
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dc.contributor.author | Jung, Younghee | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Cho, Jeong eun | - |
dc.contributor.author | Kim, Hyung-sook | - |
dc.contributor.author | Kim, Nak-Hyun | - |
dc.contributor.author | Kim, Taek Soo | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Chung, Jae-Yong | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Bang, Ji Hwan | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Park, Sang-Won | - |
dc.contributor.author | Bin Kim, Hong | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.date.accessioned | 2024-04-26T01:07:15Z | - |
dc.date.available | 2024-04-26T01:07:15Z | - |
dc.date.created | 2020-07-17 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.citation | International Journal of Antimicrobial Agents, Vol.43 No.2, pp.179-183 | - |
dc.identifier.issn | 0924-8579 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199717 | - |
dc.description.abstract | There have been few clinical studies on the association between the 24-h area under the concentration-time curve (AUC24) to minimum inhibitory concentration (MIC) ratio and vancomycin treatment outcomes in methicillin-resistant Staphylococcus aureus (MRSA) infections. Patients with MRSA bacteraemia between July 2009 and January 2012 were analysed retrospectively. All adult patients treated with vancomycin for = 72 h without dialysis were included. The MIC was determined by Etest and broth microdilution (BMD). Initial steady-state AUC24 was estimated using a Bayesian model, and the AUC24/MIC cut-off value for differentiating treatment success and failure was calculated by classification and regression tree (CART) analysis. In total, 76 patients were enrolled; vancomycin treatment failure occurred in 20 patients (26.3%). Catheter-related infection was the most frequent (35.5%), followed by surgical site infection (26.3%), whilst 25 (32.9%) had complicated infections. In univariate analysis, decreased MRSA vancomycin susceptibility (MIC = 1.5 mg/L) and vancomycin trough levels (15-20 mg/L) were not associated with treatment outcomes. In the CART analysis, low initial vancomycin AUC24/MIC (< 430 by Etest; < 398.5 by BMD) was associated with a higher treatment failure rate (50.0% vs. 25.0%, P = 0.039 by Etest; 45.0% vs. 23.2%; P = 0.065 by BMD). In multivariate analysis, low initial vancomycin AUC24/MIC was a significant risk factor for treatment failure [ adjusted odds ratio (aOR) = 4.39, 95% confidence interval (CI), 1.26-15.35 by Etest; aOR = 3.73, 95% CI 1.10-12.61 by BMD]. In MRSA bacteraemia, a low initial vancomycin AUC24/MIC is an independent risk factor for vancomycin treatment failure. (C) 2013 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Area under the concentration-time curve to minimum inhibitory concentration ratio as a predictor of vancomycin treatment outcome in methicillin-resistant Staphylococcus aureus bacteraemia | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijantimicag.2013.10.017 | - |
dc.citation.journaltitle | International Journal of Antimicrobial Agents | - |
dc.identifier.wosid | 000330189000014 | - |
dc.identifier.scopusid | 2-s2.0-84893702242 | - |
dc.citation.endpage | 183 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 179 | - |
dc.citation.volume | 43 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chung, Jae-Yong | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Kim, Eu Suk | - |
dc.contributor.affiliatedAuthor | Park, Kyoung Un | - |
dc.contributor.affiliatedAuthor | Park, Sang-Won | - |
dc.contributor.affiliatedAuthor | Kim, Nam Joong | - |
dc.contributor.affiliatedAuthor | Oh, Myoung-don | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | PHARMACODYNAMICS | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordAuthor | Vancomycin | - |
dc.subject.keywordAuthor | Methicillin-resistant Staphylococcus aureus | - |
dc.subject.keywordAuthor | Bacteraemia | - |
dc.subject.keywordAuthor | Area under the concentration-time curve | - |
dc.subject.keywordAuthor | Minimum inhibitory concentration | - |
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