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Differences in characteristics between healthcare-associated and community-acquired infection in community-onset Klebsiella pneumoniae bloodstream infection in Korea
DC Field | Value | Language |
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dc.contributor.author | Jung, Younghee | - |
dc.contributor.author | Lee, Myung Jin | - |
dc.contributor.author | Sin, Hye-Yun | - |
dc.contributor.author | Kim, Nak-Hyun | - |
dc.contributor.author | Hwang, Jeong-Hwan | - |
dc.contributor.author | Park, Jinyong | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Park, Sang-Won | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.contributor.author | Kim, Nam-Joong | - |
dc.contributor.author | Kim, Eui-Chong | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Oh, Myoung-Don | - |
dc.date.accessioned | 2024-04-26T01:07:51Z | - |
dc.date.available | 2024-04-26T01:07:51Z | - |
dc.date.created | 2021-03-24 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.citation | BMC Infectious Diseases, Vol.12, p. 239 | - |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199727 | - |
dc.description.abstract | Background: Healthcare-associated (HCA) infection has emerged as a new epidemiological category. The aim of this study was to evaluate the impact of HCA infection on mortality in community-onset Klebsiella pneumoniae bloodstream infection (KpBSI). Methods: We conducted a retrospective study in two tertiary-care hospitals over a 6-year period. All adult patients with KpBSI within 48 hours of admission were enrolled. We compared the clinical characteristics of HCA and community-acquired (CA) infection, and analyzed risk factors for mortality in patients with community-onset KpBSI. Results: Of 553 patients with community-onset KpBSI, 313 (57%) were classified as HCA-KpBSI and 240 (43%) as CA-KpBSI. In patients with HCA-KpBSI, the severity of the underlying diseases was higher than in patients with CA-KpBSI. Overall the most common site of infection was the pancreatobiliary tract. Liver abscess was more common in CA-KpBSI, whereas peritonitis and primary bacteremia were more common in HCA-KpBSI. Isolates not susceptible to extended-spectrum cephalosporin were more common in HCA-KpBSI than in CA-KpBSI (9% [29/313] vs. 3% [8/240]; p = 0.006). Overall 30-day mortality rate was significantly higher in HCA-KpBSI than in CA-KpBSI (22% [70/313] vs. 11% [27/240]; p = 0.001). In multivariate analysis, high Charlson's weighted index of co-morbidity, high Pitt bacteremia score, neutropenia, polymicrobial infection and inappropriate empirical antimicrobial therapy were significant risk factors for 30-day mortality. Conclusions: HCA-KpBSI in community-onset KpBSI has distinctive characteristics and has a poorer prognosis than CA-KpBSI, but HCA infection was not an independent risk factor for 30-day mortality. | - |
dc.language | 영어 | - |
dc.publisher | BioMed Central | - |
dc.title | Differences in characteristics between healthcare-associated and community-acquired infection in community-onset Klebsiella pneumoniae bloodstream infection in Korea | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/1471-2334-12-239 | - |
dc.citation.journaltitle | BMC Infectious Diseases | - |
dc.identifier.wosid | 000312373800001 | - |
dc.identifier.scopusid | 2-s2.0-84866854617 | - |
dc.citation.startpage | 239 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Kim, Eu Suk | - |
dc.contributor.affiliatedAuthor | Park, Sang-Won | - |
dc.contributor.affiliatedAuthor | Park, Kyoung Un | - |
dc.contributor.affiliatedAuthor | Kim, Hong Bin | - |
dc.contributor.affiliatedAuthor | Kim, Nam-Joong | - |
dc.contributor.affiliatedAuthor | Kim, Eui-Chong | - |
dc.contributor.affiliatedAuthor | Oh, Myoung-Don | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | STAPHYLOCOCCUS-AUREUS BACTEREMIA | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | LIVER-ABSCESS | - |
dc.subject.keywordPlus | ANTIMICROBIAL TREATMENT | - |
dc.subject.keywordPlus | CLINICAL-SIGNIFICANCE | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | DEFINITION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordAuthor | Klebsiella pneumoniae | - |
dc.subject.keywordAuthor | Bacteremia | - |
dc.subject.keywordAuthor | Community-acquired infections | - |
dc.subject.keywordAuthor | Healthcare-associated | - |
dc.subject.keywordAuthor | Community-onset infection | - |
dc.subject.keywordAuthor | Epidemiology | - |
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