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Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis
DC Field | Value | Language |
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dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Jeon, Jae Hyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Sung-Han | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.contributor.author | Choe, Kang Won | - |
dc.date.accessioned | 2024-04-26T01:12:30Z | - |
dc.date.available | 2024-04-26T01:12:30Z | - |
dc.date.created | 2023-05-01 | - |
dc.date.issued | 2009-02 | - |
dc.identifier.citation | Diagnostic Microbiology and Infectious Disease, Vol.63 No.2, pp.182-187 | - |
dc.identifier.issn | 0732-8893 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199757 | - |
dc.description.abstract | The whole-blood interferon-gamma enzyme-linked immunosorbent assay (QuantiFERON-TB Gold [QFT-G]; Cellestis, Carnegie, Australia) has been studied mainly for diagnosing active pulmonary tuberculosis (TB) or latent TB. We prospectively evaluated its diagnostic usefulness in patients Suspected with extrapulmonary TB (EP-TB). Of the 100 adult patients with suspected EP-TB, 43 were classified as "confirmed" EP-TB and 5 as "probable" EP-TB. Of the 48 with EP-TB, 27 (56%) were diagnosed with TB lymphadenitis and 11 (17%) with skeletal TB. The overall sensitivity and specificity of the assay were 69% (95% confidence interval [CI(95)], 53-81%) and 82% (CI(95), 69-91%), respectively. Among 44 patients presented with cervical lymphadenopathy, the QFT-G assay showed 86% (CI(95), 64-97%) sensitivity and 87% (CI(95), 66-97%) specificity, whereas in 28 with skeletal involvement, the sensitivity and specificity of the assay were 45% (CI(95), 17-77%) and 81% (CI(95), 54-96%), respectively. These suboptimal diagnostic performances suggest that the QFT-G assay alone is not sufficient for the diagnosis of EP-TB. (c) 2009 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.diagmicrobio.2008.10.013 | - |
dc.citation.journaltitle | Diagnostic Microbiology and Infectious Disease | - |
dc.identifier.wosid | 000263212100010 | - |
dc.identifier.scopusid | 2-s2.0-58149522114 | - |
dc.citation.endpage | 187 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 182 | - |
dc.citation.volume | 63 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Wan Beom | - |
dc.contributor.affiliatedAuthor | Park, Kyoung Un | - |
dc.contributor.affiliatedAuthor | Kim, Nam Joong | - |
dc.contributor.affiliatedAuthor | Oh, Myoung-don | - |
dc.contributor.affiliatedAuthor | Kim, Hong Bin | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CELL-BASED ASSAY | - |
dc.subject.keywordPlus | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject.keywordPlus | SKIN-TEST | - |
dc.subject.keywordPlus | PULMONARY TUBERCULOSIS | - |
dc.subject.keywordPlus | ACTIVE PULMONARY | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | TESTS | - |
dc.subject.keywordPlus | LYMPHADENITIS | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | ANTIGENS | - |
dc.subject.keywordAuthor | Tuberculosis | - |
dc.subject.keywordAuthor | Interferon-gamma | - |
dc.subject.keywordAuthor | Diagnosis | - |
dc.subject.keywordAuthor | Lymphadenitis | - |
dc.subject.keywordAuthor | Spondylitis | - |
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