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Cavomycins A−C, Linear Oligomer Depsipeptides from an Annelid-Associated Streptomyces cavourensis

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dc.contributor.authorWang, Weihong-
dc.contributor.authorLee, JunI-
dc.contributor.authorRoh, Eun-
dc.contributor.authorShetye, Gauri-
dc.contributor.authorCao, Jin-
dc.contributor.authorMcAlpine, James-
dc.contributor.authorPauli, Guido-
dc.contributor.authorFranzblau, Scott-
dc.contributor.authorVu, Thi Hanh Nguyen-
dc.contributor.authorQuach, Ngoc Tung-
dc.contributor.authorOh, Eunseok-
dc.contributor.authorPark, Kyu-Hyung-
dc.contributor.authorPark, Chanyoon-
dc.contributor.authorCho, Youbin-
dc.contributor.authorJang, Hyeseon-
dc.contributor.authorHan, Song Joo-
dc.contributor.authorKim, Hiyoung-
dc.contributor.authorCho, Sanghyun-
dc.contributor.authorPhi, Quyet-Tien-
dc.contributor.authorKang, Heonjoong-
dc.date.accessioned2024-04-26T02:34:41Z-
dc.date.available2024-04-26T02:34:41Z-
dc.date.created2024-04-26-
dc.date.created2024-04-26-
dc.date.issuedACCEPT-
dc.identifier.citationJournal of Natural Products-
dc.identifier.issn0163-3864-
dc.identifier.urihttps://hdl.handle.net/10371/199798-
dc.description.abstractThree unique linear oligomeric depsipeptides, designated as cavomycins A−C (1−3), were identified from Streptomyces cavourensis, a gut bacterium associated with the annelid Paraleonnates uschakovi. The structures of these depsipeptides were determined through a combination of spectroscopic methods and chemical derivatization techniques, including methanolysis, the modified Moshers method, advanced Marfeys methods, and phenylglycine methyl ester derivatization. The unique dipeptidyl residue arrangements in compounds 1−3 indicate that they are not degradation products of valinomycin. Compound 2 and its methylation derivative 2a exhibited antiproliferative activity against PANC-1 pancreatic cancer cells with IC50 values of 1.2 and 1.7 μM, respectively.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleCavomycins A−C, Linear Oligomer Depsipeptides from an Annelid-Associated Streptomyces cavourensis-
dc.typeArticle-
dc.identifier.doi10.1021/acs.jnatprod.3c01275-
dc.citation.journaltitleJournal of Natural Products-
dc.identifier.wosid001180330100001-
dc.identifier.scopusid2-s2.0-85187117074-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKang, Heonjoong-
dc.type.docTypeArticle-
dc.description.journalClass1-
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