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Cavomycins A−C, Linear Oligomer Depsipeptides from an Annelid-Associated Streptomyces cavourensis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, Weihong | - |
dc.contributor.author | Lee, JunI | - |
dc.contributor.author | Roh, Eun | - |
dc.contributor.author | Shetye, Gauri | - |
dc.contributor.author | Cao, Jin | - |
dc.contributor.author | McAlpine, James | - |
dc.contributor.author | Pauli, Guido | - |
dc.contributor.author | Franzblau, Scott | - |
dc.contributor.author | Vu, Thi Hanh Nguyen | - |
dc.contributor.author | Quach, Ngoc Tung | - |
dc.contributor.author | Oh, Eunseok | - |
dc.contributor.author | Park, Kyu-Hyung | - |
dc.contributor.author | Park, Chanyoon | - |
dc.contributor.author | Cho, Youbin | - |
dc.contributor.author | Jang, Hyeseon | - |
dc.contributor.author | Han, Song Joo | - |
dc.contributor.author | Kim, Hiyoung | - |
dc.contributor.author | Cho, Sanghyun | - |
dc.contributor.author | Phi, Quyet-Tien | - |
dc.contributor.author | Kang, Heonjoong | - |
dc.date.accessioned | 2024-04-26T02:34:41Z | - |
dc.date.available | 2024-04-26T02:34:41Z | - |
dc.date.created | 2024-04-26 | - |
dc.date.created | 2024-04-26 | - |
dc.date.created | 2024-04-26 | - |
dc.date.issued | 2024-03 | - |
dc.identifier.citation | Journal of Natural Products, Vol.87 No.4, pp.976-983 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://hdl.handle.net/10371/199798 | - |
dc.description.abstract | Three unique linear oligomeric depsipeptides, designated as cavomycins A−C (1−3), were identified from Streptomyces cavourensis, a gut bacterium associated with the annelid Paraleonnates uschakovi. The structures of these depsipeptides were determined through a combination of spectroscopic methods and chemical derivatization techniques, including methanolysis, the modified Moshers method, advanced Marfeys methods, and phenylglycine methyl ester derivatization. The unique dipeptidyl residue arrangements in compounds 1−3 indicate that they are not degradation products of valinomycin. Compound 2 and its methylation derivative 2a exhibited antiproliferative activity against PANC-1 pancreatic cancer cells with IC50 values of 1.2 and 1.7 μM, respectively. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Cavomycins A−C, Linear Oligomer Depsipeptides from an Annelid-Associated Streptomyces cavourensis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.jnatprod.3c01275 | - |
dc.citation.journaltitle | Journal of Natural Products | - |
dc.identifier.wosid | 001180330100001 | - |
dc.identifier.scopusid | 2-s2.0-85187117074 | - |
dc.citation.endpage | 983 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 976 | - |
dc.citation.volume | 87 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kang, Heonjoong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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