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Effect of Gamma Irradiation on the Osteoinductivity of Demineralized Dentin Matrix for Allografts: A Preliminary Study

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dc.contributor.authorKu, Jeong Kui-
dc.contributor.authorKim, Il hyung-
dc.contributor.authorUm, In Woong-
dc.contributor.authorKim, Bo Hyun-
dc.contributor.authorYun, Pil Young-
dc.date.accessioned2024-05-01T01:29:06Z-
dc.date.available2024-05-01T01:29:06Z-
dc.date.created2022-04-13-
dc.date.issued2022-03-
dc.identifier.citationJournal of Functional Biomaterials, Vol.13 No.1, p. 14-
dc.identifier.issn2079-4983-
dc.identifier.urihttps://hdl.handle.net/10371/200067-
dc.description.abstractDemineralized dentin matrix (DDM) treated with gamma irradiation (GR) has shown promising results as an allograft without any adverse effects in in vivo and clinical studies. The purpose of this study was to evaluate the effects of 15 and 25 kGy GR on the osteoinductive properties of DDM at extra-skeletal sites. As a control group, non-irradiated DDM powder was implanted into the right subcutaneous tissues of the dorsal thigh muscles of 20 nude mice. DDM powder irradiated with 15 and 25 kGy was implanted into the left side. After two and four weeks, the bone mineral density (BMD) was measured with dual-energy X-ray absorptiometry. After confirming osteoblast- and osteoclast-specific activities by alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) staining, a histological analysis was performed to measure the new bone formation and the number of osteoblasts and osteoclast-like cells on the surface of the DDMs. Histomorphometry was used to calculate the new bone formation area on the surface of the DDM particles (DDMs). The BMD in all the groups increased from two and four weeks without statistically significant differences. The osteoblasts were dominantly activated on DDM without GR, and DDM treated with 25 kGy compared to DDM treated with 15 kGy. Among the groups, new bone formation was identified in all the groups at each time point. In conclusion, GR at doses of 15 and 25 kGy does not affect the osteoinductive properties of DDM powder.-
dc.language영어-
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)-
dc.titleEffect of Gamma Irradiation on the Osteoinductivity of Demineralized Dentin Matrix for Allografts: A Preliminary Study-
dc.typeArticle-
dc.identifier.doi10.3390/jfb13010014-
dc.citation.journaltitleJournal of Functional Biomaterials-
dc.identifier.wosid000774986700001-
dc.identifier.scopusid2-s2.0-85124098358-
dc.citation.number1-
dc.citation.startpage14-
dc.citation.volume13-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorYun, Pil Young-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusRADIATION STERILIZATION-
dc.subject.keywordPlusBONE-MATRIX-
dc.subject.keywordPlusINACTIVATION-
dc.subject.keywordPlusOSTEOCLASTS-
dc.subject.keywordPlusVIRUS-
dc.subject.keywordPlusTRANSMISSION-
dc.subject.keywordPlusRESORPTION-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlusBIOLOGY-
dc.subject.keywordPlusCARRIER-
dc.subject.keywordAuthorbone graft substitutes-
dc.subject.keywordAuthordemineralized dentin matrix-
dc.subject.keywordAuthorosteoinductivity-
dc.subject.keywordAuthorgamma irradiation-
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Yun, Pil Young윤필영
(기금)부교수
  • School of Dentistry
  • Department of Dentistry
Research Area Dentistry, Oral Pathology, Oral and Maxillofacial Surgery, 구강병리학, 구강악안면외과학, 치의학

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