Detailed Information

The role of p53 status on the synergistic effect of CKD-602 and cisplatin on oral squamous cell carcinoma cell lines

Cited 3 time in Web of Science Cited 3 time in Scopus

Choi, Hyeong Sim; Kim, Young Kyun; Yun, Pil Young

Issue Date
Kluwer Academic Publishers
Molecular Biology Reports, Vol.46 No.1, pp.617-625
The purpose of this study was to evaluate the synergistic apoptotic effect of CKD-602 in combination with cisplatin on different p53 statuses of oral squamous cell carcinoma (OSCC) cell lines, YD-8, YD-9, and YD-38. MTT assays were used to evaluate the inhibitory effect of the treatments modality on cell growth. The combination index was calculated using CompuSyn software. Detection of cell death was carried out using the propidium iodide (PI)/RNase staining assay, Annexin V/PI double staining assay, and Western blotting. Combination treatment using CKD-602 and cisplatin inhibited proliferation and increased the apoptotic effect on the three OSCC cell lines. Apoptotic cell death was detected in the cell lines, and significant synergistic effects of CKD-602 in combination with cisplatin were observed despite the differences in p53 status. From these results, it was suggested that the combination of CKD-602 with cisplatin might be a potential therapeutic strategy for OSCC. In particular, cell line-specific therapy is necessary because of the differences in treatment response based on p53 status.
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

Yun, Pil Young Image

Yun, Pil Young윤필영
  • School of Dentistry
  • Department of Dentistry
Research Area Dentistry, Oral Pathology, Oral and Maxillofacial Surgery, 구강병리학, 구강악안면외과학, 치의학


Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.