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Analysis of the cytokine profiles of the synovial fluid in a normal temporomandibular joint: Preliminary study

Cited 45 time in Web of Science Cited 48 time in Scopus

Kim, Young Kyun; Kim, Su Gwan; Kim, Bum Soo; Lee, Jeong Yun; Yun, Pil Young; Bae, Ji Hyun; Oh, Ji Su; Ahn, Jong Mo; Kim, Jae Sung; Lee, Sook Young

Issue Date
Churchill Livingstone
Journal of Cranio-Maxillo-Facial Surgery, Vol.40 No.8, pp.E337-E341
The purpose of this study was to compare the cytokine profiles of the synovial fluid from the temporomandibular joint (TMJ) spaces of normal individuals and temporomandibular disorder (TMD) patients. Thirty-four patients with planned orthognathic surgery did not present abnormalities of the TMJ on magnetic resonance images and radiographs and did not show the symptoms identified by the Research Diagnostic Criteria for TMD (RDC-TMD); as a result, they were assigned to the control group. Twenty-two patients who sought treatment for TMD during the same period were assigned to the TMD group. Synovial fluid was collected from superior TMJ spaces, and cytokine expression was analysed by an enzyme-linked immunosorbent assay (ELISA). Significant differences were tested using Fisher's exact test (p < 0.05). Granulocyte Macrophage Colony stimulating Factor (GM-CSF), interferon (INF), interleukin (IL)-1 beta, IL-2, IL-6, IL-8, IL-10 and tumour necrosis factor (TNF)-alpha were detected in the TMD group, whereas no cytokines were detected in the control group. The most prevalent cytokines in the TMD group were IL-1 beta, IL-6 and GM-CSF. IL-4 and IL-5 were not detected in either the TMD group or in the control group. None of the cytokines that were detected in patients with TMD were found in the articular spaces of normal individuals. (C) 2012 European Association for Cranio-Maxillo-Facial Surgery.
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Yun, Pil Young윤필영
  • School of Dentistry
  • Department of Dentistry
Research Area Dentistry, Oral Pathology, Oral and Maxillofacial Surgery, 구강병리학, 구강악안면외과학, 치의학


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