Publications
Detailed Information
Salivary cytokine profiles in primary Sjögren's syndrome differ from those in non-sjögren sicca in terms of TNF-α levels and Th-1/Th-2 ratios : Salivary cytokine profiles in primary Sjogren's syndrome differ from those in non-Sjogren sicca in terms of TNF-alpha levels and Th-1/Th-2 ratios
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Eun Ha | - |
dc.contributor.author | Lee, Yun Jong | - |
dc.contributor.author | Hyon, Joon Young | - |
dc.contributor.author | Yun, Pil Young | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.date.accessioned | 2024-05-01T01:36:42Z | - |
dc.date.available | 2024-05-01T01:36:42Z | - |
dc.date.created | 2019-10-28 | - |
dc.date.created | 2019-10-28 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.citation | Clinical and Experimental Rheumatology, Vol.29 No.6, pp.970-976 | - |
dc.identifier.issn | 0392-856X | - |
dc.identifier.uri | https://hdl.handle.net/10371/200204 | - |
dc.description.abstract | Objective To compare salivary cytokine profiles in patients with primary Sjogren's syndrome (pSS), non-SS sicca controls, and non-sicca controls, and to investigate whether cytokine levels are correlated with clinical parameters of ASS patients. Methods Un-stimulated whole saliva samples were obtained from pSS patients (n=30) classified according to the criteria of the American European Consensus Group. Age- and gender-matched non-SS sicca patients (n=30) and non-sicca subjects (n=25) served as controls. Salivary IFN-gamma. TNF-alpha, IL-1, IL-4, IL-6, IL-10, IL-12p40, and IL-17 levels were measured using a multiplex Luminex(R) bead-based assay. Results pSS patients and non-SS sicca controls had significantly lower salivary,flow rates (SFRs) than non-sicca controls, and pSS patients showed a more profound decrease than non-SS sicca controls. In addition, pSS patients and non-SS sicca controls had higher levels of IFN-gamma, TNF-alpha, IL-1, IL-4, IL-10, IL-12p40, and IL-17 in their saliva than non-sicca controls. Salivary TNF-alpha levels were higher in pSS patients than in non-SS sicca controls. Th-1/Th-2 ratios, represented by INF-gamma/IL-4 and TNF-alpha/IL-4 ratios, were significantly higher in pSS patients than in non-SS sicca controls. SFR was found to be correlated with INF-gamma/IL-4 ratio (r=0.411 p=0.024), and focus score to be correlated with TNF-alpha/IL-4 ratio (r=0.581, p=0.023) in pSS patients. Conclusion Th-1, Th-2, and Th17 cytokine levels were found to be elevated in the saliva of pSS patients compared with non-sicca controls. However, considerable overlap was observed between the salivary cytokine levels of pSS patients and of non-SS sicca controls. The features that most differentiated pSS and non-SS sicca were higher TNF-alpha levels and Th-1/Th-2 ratios. Th-1/Th-2 ratio was also found to be correlated with the clinical parameters of pSS. | - |
dc.language | 영어 | - |
dc.publisher | Pacini Editore SpA | - |
dc.title | Salivary cytokine profiles in primary Sjögren's syndrome differ from those in non-sjögren sicca in terms of TNF-α levels and Th-1/Th-2 ratios | - |
dc.title.alternative | Salivary cytokine profiles in primary Sjogren's syndrome differ from those in non-Sjogren sicca in terms of TNF-alpha levels and Th-1/Th-2 ratios | - |
dc.type | Article | - |
dc.citation.journaltitle | Clinical and Experimental Rheumatology | - |
dc.identifier.wosid | 000300032600011 | - |
dc.identifier.scopusid | 2-s2.0-84863296483 | - |
dc.citation.endpage | 976 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 970 | - |
dc.citation.volume | 29 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Yun Jong | - |
dc.contributor.affiliatedAuthor | Hyon, Joon Young | - |
dc.contributor.affiliatedAuthor | Yun, Pil Young | - |
dc.contributor.affiliatedAuthor | Song, Yeong Wook | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | MESSENGER-RNA EXPRESSION | - |
dc.subject.keywordPlus | TIGHT JUNCTION STRUCTURE | - |
dc.subject.keywordPlus | GLAND CELL-LINE | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | AUTOIMMUNE EXOCRINOPATHY | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | ETANERCEPT | - |
dc.subject.keywordAuthor | Sjogren&apos | - |
dc.subject.keywordAuthor | s syndrome | - |
dc.subject.keywordAuthor | sicca | - |
dc.subject.keywordAuthor | saliva | - |
dc.subject.keywordAuthor | cytokine | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.