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Apoptotic effect of CKD-602 (Camtobell (R)) on oral squamous cell carcinoma cell lines

Cited 8 time in Web of Science Cited 8 time in Scopus

Ok, Yong Ju; Myoung, Hoon; Kim, Young Kyun; Lee, Jong Ho; Kim, Myung Jin; Yun, Pil Young

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Pergamon Press Ltd.
Oral Oncology, Vol.45 No.3, pp.266-272
The purposes of this study were to measure the cytotoxic effect of CKD-602 on oral squamous cell carcinoma (OSCC) cell lines, to evaluate the apoptotic aspect of dead cells, and to identify the signaling molecules involved in apoptosis. The human OSCC cell lines A253, HSC-3 and KB were treated with CKD-602. The apoptotic proportion of the cells was analyzed using flow cytometry. The expression of Bax, Bcl-2, and p53 were detected by western blotting analysis. CKD-602 showed excellent cytotoxicity to the OSCC cell lines. Most cell death was attributed to apoptosis rather than necrosis. CKD-602 induced the down-regulation of Bcl-2 in A253 and HSC-3 cells, and p53 was expressed in the KB cell line after treatment with CKD-602. (C) 2008 Elsevier Ltd. All rights reserved.
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Yun, Pil Young윤필영
  • School of Dentistry
  • Department of Dentistry
Research Area Dentistry, Oral Pathology, Oral and Maxillofacial Surgery, 구강병리학, 구강악안면외과학, 치의학


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