Publications

Detailed Information

악관절환자에서 Synovial fluid에 대한 단백질체 분석에 관한 연구 : The analysis of synovial fluid by proteomics from TMD

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors

변은선; 김태우; 김상균; 박태일; 박준우; 윤필영; 김영균; 채창훈

Issue Date
2008-04
Publisher
대한구강악안면외과학회
Citation
대한구강악안면외과학회지, Vol.34 No.2, pp.113-118
Abstract
Temporomandibular joint disorder (TMD) can induce severe pain but, its pathogenic mechanisms remain poorly understood. In this study, we analyzed proteomes of human synovial fluid in the superior joint space in the patients with TMD, which is obtained during the treatment arthrocentesis. Weve got this result that one of the spots was consistently down-regulated in synovial fluid of patients with TMD from analysis of protein pattern. Its molecular weight was estimated to be 33 kDa. Synoviolin was identified in our proteomics analysis of LC/MS/MS. This protein was recently reported as one of the proteins that might affect rheumatoid arthritis (RA). Synoviolin that might be associated with RA was detected in synovial fluid of patients with TMD. We can conclude that synoviolin might be involved not only in the pathogenesis of RA but also in TMD. In result, synoviolin might be involved in the pathogenesis of TMD and can be candidates as new therapeutic targets of TMD or early detection biomarkers.
ISSN
2234-7550
URI
https://hdl.handle.net/10371/200274
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

Yun, Pil Young Image

Yun, Pil Young윤필영
(기금)부교수
  • School of Dentistry
  • Department of Dentistry
Research Area Dentistry, Oral Pathology, Oral and Maxillofacial Surgery, 구강병리학, 구강악안면외과학, 치의학

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share