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구강암 세포주에 대한 CKD-602의 항암 효과 : Anticancer effect of CKD-602(belotecan, camtobell.) on the oral cancer cell lines
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤필영 | - |
dc.contributor.author | 옥용주 | - |
dc.contributor.author | 명훈 | - |
dc.contributor.author | 이종호 | - |
dc.contributor.author | 김명진 | - |
dc.date.accessioned | 2024-05-01T01:46:46Z | - |
dc.date.available | 2024-05-01T01:46:46Z | - |
dc.date.created | 2022-06-14 | - |
dc.date.issued | 2005-02 | - |
dc.identifier.citation | 대한구강악안면외과학회지, Vol.31 No.1, pp.7-12 | - |
dc.identifier.issn | 2234-7550 | - |
dc.identifier.uri | https://hdl.handle.net/10371/200294 | - |
dc.description.abstract | Purpose: CKD-602, a newly developed water-soluble campthotecin analogue, is a anticancer agent which act as a DNA topoisomerase I inhibitor. CKD-602 is known as more potent and tolerable agent. The main purposes of this study were to measure the cytotoxic effect of CKD-602 on the oral cancer cell lines and to evaluate the apoptotic aspect of dead cells. Materials and Methods: To determine the cytotoxic effect of CKD-602 on the oral cancer cell lines in comparison with various cell lines, such as lung cancer and colon cancer cell lines, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was performed. And apoptosis was analyzed using fluorescence-activated cell sorting(FACS) system. Results: CKD-602 decreased the viability of malignant cells in a dose dependent manner and in a time dependent manner. CKD-602 showed excellent cytotoxicity to the oral cancer cell lines. Also, apoptotic portion was increased in a dose dependent manner. Conclusion: These findings indicated that CKD-602 induced apoptotic cell death in the various cell lines including oral cancer cell lines. From the results, it was suggested that CKD-602 would be a potential therapeutic agent for the oral cancer. More successive researches on the anticancer effect of CKD-602 should be performed. | - |
dc.language | 한국어 | - |
dc.publisher | 대한구강악안면외과학회 | - |
dc.title | 구강암 세포주에 대한 CKD-602의 항암 효과 | - |
dc.title.alternative | Anticancer effect of CKD-602(belotecan, camtobell.) on the oral cancer cell lines | - |
dc.type | Article | - |
dc.citation.journaltitle | 대한구강악안면외과학회지 | - |
dc.citation.endpage | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 7 | - |
dc.citation.volume | 31 | - |
dc.identifier.kciid | ART001128880 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | 윤필영 | - |
dc.contributor.affiliatedAuthor | 명훈 | - |
dc.contributor.affiliatedAuthor | 이종호 | - |
dc.contributor.affiliatedAuthor | 김명진 | - |
dc.description.journalClass | 2 | - |
dc.subject.keywordAuthor | CKD-602, Camptothecin, Topoisomerase-I inhibitor, Oral cancer, Apoptosis | - |
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