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Improvement of halitosis by probiotic bacterium Weissella cibaria CMU: A randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | Han, Hee-seung | - |
dc.contributor.author | Yum, Haeji | - |
dc.contributor.author | Cho, Young-Dan | - |
dc.contributor.author | Kim, Sungtae | - |
dc.date.accessioned | 2024-05-02T05:37:48Z | - |
dc.date.available | 2024-05-02T05:37:48Z | - |
dc.date.created | 2023-03-16 | - |
dc.date.created | 2023-03-16 | - |
dc.date.created | 2023-03-16 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.citation | Frontiers in Microbiology, Vol.14, p. 1108762 | - |
dc.identifier.issn | 1664-302X | - |
dc.identifier.uri | https://hdl.handle.net/10371/200398 | - |
dc.description.abstract | Several in vitro and in vivo studies have evaluated the effect of probiotics on oral health; however, human clinical studies are still limited. Therefore, this study aimed to examine the effects of Weissella cibaria Chonnam Medical University (CMU)-containing tablets on halitosis. This randomized, double-blinded, placebo-controlled study included 100 adults with halitosis (age, 20-70 years). The participants were randomly assigned to the test group (n = 50) and control group (n = 50). One tablet [1 x 10(8) colony forming units (CFU)/tablet] was to be taken each day over 8 weeks. The concentrations of volatile sulfur compounds (VSCs), bad breath improvement scores, and oral colonization of W. cibaria were measured. Psychosocial indicators including depression, self-esteem, oral health-related quality of life, and subjective oral health status were evaluated. Most variables were assessed at baseline, 4, and 8 weeks, and W. cibaria number and safety variables were assessed at baseline and 8 weeks. Intergroup comparisons were carried out using Student's t-test, Chi-square test, or Fisher's exact test on per-protocol analysis. Intragroup differences before and after intake were analyzed using the linear mixed-effect model (LMM). Per-protocol analysis was carried out in the test group (n = 45) and control group (n = 46). Total VSC was significantly lower in the probiotics group than in the placebo group at baseline (week 0, p = 0.046) and at 8 weeks (p = 0.017). The sum of hydrogen sulfide and methyl mercaptan did not differ significantly between the groups at baseline; however, it was significantly lower in the probiotics group than in the placebo group at week 8 (p = 0.012). Bad breath improvement (BBI) scores were significantly reduced at week 8 (p = 0.006) in the probiotics group. Statistically significant intergroup differences were observed for changes in the level of W. cibaria at week 8 (p < 0.001). Psychological indicators significantly improved from baseline to week 8 in the probiotics group. No safety issues were observed in either group. The levels of W. cibaria was higher in patients with halitosis using W. cibaria CMU-containing tablets. The subjective degree of bad breath and psychological indicators were improved in patients with halitosis using W. cibaria CMU-containing tablets. | - |
dc.language | 영어 | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Improvement of halitosis by probiotic bacterium Weissella cibaria CMU: A randomized controlled trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fmicb.2023.1108762 | - |
dc.citation.journaltitle | Frontiers in Microbiology | - |
dc.identifier.wosid | 000921940000001 | - |
dc.identifier.scopusid | 2-s2.0-85147183079 | - |
dc.citation.startpage | 1108762 | - |
dc.citation.volume | 14 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Young-Dan | - |
dc.contributor.affiliatedAuthor | Kim, Sungtae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ORAL MALODOR | - |
dc.subject.keywordPlus | LACTOBACILLUS-REUTERI | - |
dc.subject.keywordPlus | CHRONIC PERIODONTITIS | - |
dc.subject.keywordPlus | HYDROGEN-SULFIDE | - |
dc.subject.keywordPlus | METHYL MERCAPTAN | - |
dc.subject.keywordPlus | ABILITY | - |
dc.subject.keywordAuthor | halitosis | - |
dc.subject.keywordAuthor | probiotics | - |
dc.subject.keywordAuthor | clinical study | - |
dc.subject.keywordAuthor | safety | - |
dc.subject.keywordAuthor | Weissella cibaria | - |
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