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Improvement of halitosis by probiotic bacterium Weissella cibaria CMU: A randomized controlled trial

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dc.contributor.authorHan, Hee-seung-
dc.contributor.authorYum, Haeji-
dc.contributor.authorCho, Young-Dan-
dc.contributor.authorKim, Sungtae-
dc.date.accessioned2024-05-02T05:37:48Z-
dc.date.available2024-05-02T05:37:48Z-
dc.date.created2023-03-16-
dc.date.created2023-03-16-
dc.date.created2023-03-16-
dc.date.issued2023-01-
dc.identifier.citationFrontiers in Microbiology, Vol.14, p. 1108762-
dc.identifier.issn1664-302X-
dc.identifier.urihttps://hdl.handle.net/10371/200398-
dc.description.abstractSeveral in vitro and in vivo studies have evaluated the effect of probiotics on oral health; however, human clinical studies are still limited. Therefore, this study aimed to examine the effects of Weissella cibaria Chonnam Medical University (CMU)-containing tablets on halitosis. This randomized, double-blinded, placebo-controlled study included 100 adults with halitosis (age, 20-70 years). The participants were randomly assigned to the test group (n = 50) and control group (n = 50). One tablet [1 x 10(8) colony forming units (CFU)/tablet] was to be taken each day over 8 weeks. The concentrations of volatile sulfur compounds (VSCs), bad breath improvement scores, and oral colonization of W. cibaria were measured. Psychosocial indicators including depression, self-esteem, oral health-related quality of life, and subjective oral health status were evaluated. Most variables were assessed at baseline, 4, and 8 weeks, and W. cibaria number and safety variables were assessed at baseline and 8 weeks. Intergroup comparisons were carried out using Student's t-test, Chi-square test, or Fisher's exact test on per-protocol analysis. Intragroup differences before and after intake were analyzed using the linear mixed-effect model (LMM). Per-protocol analysis was carried out in the test group (n = 45) and control group (n = 46). Total VSC was significantly lower in the probiotics group than in the placebo group at baseline (week 0, p = 0.046) and at 8 weeks (p = 0.017). The sum of hydrogen sulfide and methyl mercaptan did not differ significantly between the groups at baseline; however, it was significantly lower in the probiotics group than in the placebo group at week 8 (p = 0.012). Bad breath improvement (BBI) scores were significantly reduced at week 8 (p = 0.006) in the probiotics group. Statistically significant intergroup differences were observed for changes in the level of W. cibaria at week 8 (p < 0.001). Psychological indicators significantly improved from baseline to week 8 in the probiotics group. No safety issues were observed in either group. The levels of W. cibaria was higher in patients with halitosis using W. cibaria CMU-containing tablets. The subjective degree of bad breath and psychological indicators were improved in patients with halitosis using W. cibaria CMU-containing tablets.-
dc.language영어-
dc.publisherFrontiers Media S.A.-
dc.titleImprovement of halitosis by probiotic bacterium Weissella cibaria CMU: A randomized controlled trial-
dc.typeArticle-
dc.identifier.doi10.3389/fmicb.2023.1108762-
dc.citation.journaltitleFrontiers in Microbiology-
dc.identifier.wosid000921940000001-
dc.identifier.scopusid2-s2.0-85147183079-
dc.citation.startpage1108762-
dc.citation.volume14-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorCho, Young-Dan-
dc.contributor.affiliatedAuthorKim, Sungtae-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusORAL MALODOR-
dc.subject.keywordPlusLACTOBACILLUS-REUTERI-
dc.subject.keywordPlusCHRONIC PERIODONTITIS-
dc.subject.keywordPlusHYDROGEN-SULFIDE-
dc.subject.keywordPlusMETHYL MERCAPTAN-
dc.subject.keywordPlusABILITY-
dc.subject.keywordAuthorhalitosis-
dc.subject.keywordAuthorprobiotics-
dc.subject.keywordAuthorclinical study-
dc.subject.keywordAuthorsafety-
dc.subject.keywordAuthorWeissella cibaria-
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Cho, Young-Dan조영단
(기금)조교수
  • School of Dentistry
  • Department of Dentistry
Research Area Alveolar bone regeneration, Dental implant surface modification, Periomics

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