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Transcriptome and methylome analysis of periodontitis and peri-implantitis with tobacco use
DC Field | Value | Language |
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dc.contributor.author | Cho, Young-Dan | - |
dc.contributor.author | Kim, Pil-Jong | - |
dc.contributor.author | Kim, Hong-Gee | - |
dc.contributor.author | Seol, Yang-Jo | - |
dc.contributor.author | Lee, Yong-Moo | - |
dc.contributor.author | Ryoo, Hyun-Mo | - |
dc.contributor.author | Ku, Young | - |
dc.date.accessioned | 2024-05-02T05:59:22Z | - |
dc.date.available | 2024-05-02T05:59:22Z | - |
dc.date.created | 2020-05-20 | - |
dc.date.created | 2020-05-20 | - |
dc.date.created | 2020-05-20 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | Gene, Vol.727, p. 144258 | - |
dc.identifier.issn | 0378-1119 | - |
dc.identifier.uri | https://hdl.handle.net/10371/200503 | - |
dc.description.abstract | Peri-implantitis is similar to periodontitis in both symptoms and treatment; however, their level of similarity remains controversial. Here, we compared multiple cases of periodontitis and peri-implantitis through transcriptome and methylome profiling, and analyzed the effects of smoking as a typical risk factor. Human gingival tissues were obtained from 20 patients with periodontitis or peri-implantitis via periodontal surgical procedures. Total RNA and genomic DNA were isolated, and transcriptome and methylome datasets were generated. Comprehensive analysis of differential gene expression, DNA methylation, and protein-protein interactions indicated that periodontitis and peri-implantitis share biological similarities; however, hierarchical clustering between the two disease groups revealed distinct molecular characteristics. These differences might be related to structural differences in natural tooth-bone and implant-bone. Additionally, smoking differentially affected periodontitis and peri-implantitis in terms of host-defense mechanism impairment. Within the limitations of this study, the results provide evidence that peri-implantitis is distinct from periodontitis and that smoking potentially affects disease progression. Our study provides a foundation for the rational design of a large-scale study in the future for a more comprehensive analysis that includes microbiome and clinical data. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Transcriptome and methylome analysis of periodontitis and peri-implantitis with tobacco use | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.gene.2019.144258 | - |
dc.citation.journaltitle | Gene | - |
dc.identifier.wosid | 000508746800009 | - |
dc.identifier.scopusid | 2-s2.0-85076570028 | - |
dc.citation.startpage | 144258 | - |
dc.citation.volume | 727 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Young-Dan | - |
dc.contributor.affiliatedAuthor | Kim, Hong-Gee | - |
dc.contributor.affiliatedAuthor | Seol, Yang-Jo | - |
dc.contributor.affiliatedAuthor | Lee, Yong-Moo | - |
dc.contributor.affiliatedAuthor | Ryoo, Hyun-Mo | - |
dc.contributor.affiliatedAuthor | Ku, Young | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NEUTROPHILS | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | Periodontitis | - |
dc.subject.keywordAuthor | Peri-implantitis | - |
dc.subject.keywordAuthor | Next generation sequencing | - |
dc.subject.keywordAuthor | Smoking | - |
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