Publications

Detailed Information

Transcriptome and methylome analysis of periodontitis and peri-implantitis with tobacco use

DC Field Value Language
dc.contributor.authorCho, Young-Dan-
dc.contributor.authorKim, Pil-Jong-
dc.contributor.authorKim, Hong-Gee-
dc.contributor.authorSeol, Yang-Jo-
dc.contributor.authorLee, Yong-Moo-
dc.contributor.authorRyoo, Hyun-Mo-
dc.contributor.authorKu, Young-
dc.date.accessioned2024-05-02T05:59:22Z-
dc.date.available2024-05-02T05:59:22Z-
dc.date.created2020-05-20-
dc.date.created2020-05-20-
dc.date.created2020-05-20-
dc.date.issued2020-02-
dc.identifier.citationGene, Vol.727, p. 144258-
dc.identifier.issn0378-1119-
dc.identifier.urihttps://hdl.handle.net/10371/200503-
dc.description.abstractPeri-implantitis is similar to periodontitis in both symptoms and treatment; however, their level of similarity remains controversial. Here, we compared multiple cases of periodontitis and peri-implantitis through transcriptome and methylome profiling, and analyzed the effects of smoking as a typical risk factor. Human gingival tissues were obtained from 20 patients with periodontitis or peri-implantitis via periodontal surgical procedures. Total RNA and genomic DNA were isolated, and transcriptome and methylome datasets were generated. Comprehensive analysis of differential gene expression, DNA methylation, and protein-protein interactions indicated that periodontitis and peri-implantitis share biological similarities; however, hierarchical clustering between the two disease groups revealed distinct molecular characteristics. These differences might be related to structural differences in natural tooth-bone and implant-bone. Additionally, smoking differentially affected periodontitis and peri-implantitis in terms of host-defense mechanism impairment. Within the limitations of this study, the results provide evidence that peri-implantitis is distinct from periodontitis and that smoking potentially affects disease progression. Our study provides a foundation for the rational design of a large-scale study in the future for a more comprehensive analysis that includes microbiome and clinical data.-
dc.language영어-
dc.publisherElsevier BV-
dc.titleTranscriptome and methylome analysis of periodontitis and peri-implantitis with tobacco use-
dc.typeArticle-
dc.identifier.doi10.1016/j.gene.2019.144258-
dc.citation.journaltitleGene-
dc.identifier.wosid000508746800009-
dc.identifier.scopusid2-s2.0-85076570028-
dc.citation.startpage144258-
dc.citation.volume727-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorCho, Young-Dan-
dc.contributor.affiliatedAuthorKim, Hong-Gee-
dc.contributor.affiliatedAuthorSeol, Yang-Jo-
dc.contributor.affiliatedAuthorLee, Yong-Moo-
dc.contributor.affiliatedAuthorRyoo, Hyun-Mo-
dc.contributor.affiliatedAuthorKu, Young-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusNEUTROPHILS-
dc.subject.keywordPlusDISEASES-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordAuthorPeriodontitis-
dc.subject.keywordAuthorPeri-implantitis-
dc.subject.keywordAuthorNext generation sequencing-
dc.subject.keywordAuthorSmoking-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Related Researcher

Cho, Young-Dan Image

Cho, Young-Dan조영단
(기금)조교수
  • School of Dentistry
  • Department of Dentistry
Research Area Alveolar bone regeneration, Dental implant surface modification, Periomics

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share