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Chemotactic migration of newly excysted juvenile Clonorchis sinensis is suppressed by neuro-antagonists

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dc.contributor.authorLi, Shunyu-
dc.contributor.authorSong, Jin-Ho-
dc.contributor.authorKim, Tae Im-
dc.contributor.authorYoo, Won Gi-
dc.contributor.authorWon, Moo-Ho-
dc.contributor.authorDai, Fuhong-
dc.contributor.authorHong, Sung-Jong-
dc.date.accessioned2024-05-02T06:00:15Z-
dc.date.available2024-05-02T06:00:15Z-
dc.date.created2024-04-29-
dc.date.created2024-04-29-
dc.date.issued2019-08-
dc.identifier.citationPLoS Neglected Tropical Diseases, Vol.13 No.8, p. e0007573-
dc.identifier.issn1935-2727-
dc.identifier.urihttps://hdl.handle.net/10371/200518-
dc.description.abstractThe metacercariae of the Clonorchis sinensis liver fluke excyst in the duodenum of mammalian hosts, and the newly excysted juveniles (CsNEJs) migrate along the bile duct via bile chemotaxis. Cholic acid is a major component of bile that induces this migration. We investigated the neuronal control of chemotactic behavior of CsNEJs toward cholic acid. The migration of CsNEJs was strongly inhibited at sub-micromolar concentration by dopamine D-1 (LE-300 and SKF-83566), D-2 (spiramide, nemonapride, and sulpiride), and D-3 (GR-103691 and NGB-2904) receptor antagonists, as well as a dopamine reuptake inhibitor (BTCP). Neuropeptides, FMRFamide, peptide YY, and neuropeptide Y were also potent inhibitors of chemotaxis. Meanwhile, serotonergic, glutamatergic, and cholinergic inhibitors did not affect chemotaxis, with the exception of fluoxetine and CNQX. Confocal immunofluorescence analysis indicated that dopaminergic and cholinergic neurons were colocalized in the somatic muscle tissues of adult C. sinensis. Our findings suggest that dopaminergic neurons and neuropeptides play a major role in the chemotactic migration of CsNEJs to bile, and their inhibitors or modulators could be utilized to prevent their migration from the bile duct.-
dc.language영어-
dc.publisherPublic Library of Science-
dc.titleChemotactic migration of newly excysted juvenile Clonorchis sinensis is suppressed by neuro-antagonists-
dc.typeArticle-
dc.identifier.doi10.1371/journal.pntd.0007573-
dc.citation.journaltitlePLoS Neglected Tropical Diseases-
dc.identifier.wosid000490919400023-
dc.identifier.scopusid2-s2.0-85071281863-
dc.citation.number8-
dc.citation.startpagee0007573-
dc.citation.volume13-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorYoo, Won Gi-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusSCHISTOSOMA-MANSONI-
dc.subject.keywordPlusFASCIOLA-HEPATICA-
dc.subject.keywordPlusTYROSINE-HYDROXYLASE-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusSEROTONIN-
dc.subject.keywordPlusDOPAMINE-
dc.subject.keywordPlusMOTILITY-
dc.subject.keywordPlusCLONING-
dc.subject.keywordPlusACETYLCHOLINE-
dc.subject.keywordPlusTREMATODE-
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  • College of Veterinary Medicine
  • Department of Veterinary Medicine
Research Area Microbiology, Parasitology, Tropical Medicine

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