Publications
Detailed Information
Association between glucose-lowering treatment and cancer metastasis among patients with preexisting type 2 diabetes and incident malignancy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Noh, Yoojin | - |
dc.contributor.author | Jeon, Sang-Min | - |
dc.contributor.author | Shin, Sooyoung | - |
dc.date.accessioned | 2024-05-02T06:01:01Z | - |
dc.date.available | 2024-05-02T06:01:01Z | - |
dc.date.created | 2023-04-14 | - |
dc.date.created | 2023-04-14 | - |
dc.date.created | 2023-04-14 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.citation | International Journal of Cancer, Vol.144 No.7, pp.1530-1539 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://hdl.handle.net/10371/200532 | - |
dc.description.abstract | Preclinical data suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors may promote metastatic progression of preexisting cancer via nuclear factor erythroid 2-related factor 2 (NRF2) activation. We aimed to investigate the association between different glucose-lowering treatments, including DPP-4 inhibitors and metformin, both with potential NRF2 modulating effects, and new-onset metastatic cancer among type 2 diabetes patients with comorbid incident cancer. This population-based cohort study included 223,530 diabetic patients newly diagnosed with primary cancer during 2009-2011 in Korea. The patients were categorized into five study cohorts in accordance with treatment modalities during the follow-up until the end of 2016: no-antidiabetic drugs (no-AD), metformin, DPP-4 inhibitors, metformin+DPP-4 inhibitors, and insulin treatment. After propensity score (PS) matching in a 1:1 ratio against the no-AD group, 18,805 patients in metformin, 1,865 in DPP-4 inhibitors, 31,074 in metformin+DPP-4 inhibitors, and 1,895 patients in insulin groups were identified for cohort entry and analyzed against the corresponding number of no-AD patients in each PS-matched comparison pair. Metastatic risk was lower with metformin plus or minus DPP-4 inhibitors (HR 0.84, 95% CI 0.79-0.90 and 0.87, 0.80-0.95, respectively), not significantly associated with DPP-4 inhibitors (0.99, 0.77-1.29) except after thyroid cancer (3.89, 1.01-9.64), and higher with insulin therapy (1.81, 1.46-2.24) compared to no-AD use for all cancers combined. In conclusion, DPP-4 inhibitor therapy was not associated with significant risk of cancer metastasis relative to no-AD therapy, irrespective of patient age and sex, except after thyroid cancer, while metastatic risk was decreased with metformin treatment among type 2 diabetes patients with preexisting cancer. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Association between glucose-lowering treatment and cancer metastasis among patients with preexisting type 2 diabetes and incident malignancy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ijc.31870 | - |
dc.citation.journaltitle | International Journal of Cancer | - |
dc.identifier.wosid | 000457773000006 | - |
dc.identifier.scopusid | 2-s2.0-85058696442 | - |
dc.citation.endpage | 1539 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 1530 | - |
dc.citation.volume | 144 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Jeon, Sang-Min | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PEPTIDASE 4 INHIBITORS | - |
dc.subject.keywordPlus | CELL-CYCLE ARREST | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | METFORMIN | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | NRF2 | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | type 2 diabetes | - |
dc.subject.keywordAuthor | antidiabetic drug | - |
dc.subject.keywordAuthor | dipeptidyl peptidase-4 inhibitor | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.