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Analysis of the effect of oral midazolam and triazolam premedication before general anesthesia in patients with disabilities with difficulty in cooperation

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Authors

Lim, Seon Woo; So, Eunsun; Yun, Hye Joo; Karm, Myong-Hwan; Chang, Juhea; Lee, Hanbin; Kim, Hyun Jeong; Seo, Kwang Suk

Issue Date
2018-08
Publisher
대한치과마취과학회
Citation
Journal of Dental Anesthesia and Pain Medicine, Vol.18 No.4, pp.245-254
Abstract
Background: When performing dental treatment under general anesthesia in adult patients who have difficulty cooperating due to intellectual disabilities, anesthesia induction may be difficult as well. In particular, patients who refuse to come into the dental office or sit in the dental chair may have to be forced to do so. However, for adult patients with a large physique, physical restraint may be difficult, while oral sedatives as premedication may be helpful. Here, a retrospective analysis was performed to investigate the effect of oral sedatives.
Methods: A hospital-based medical information database was searched for patients who were prescribed oral midazolam or triazolam between January 2009 and December 2017. Pre-anesthesia evaluation, anesthesia, and anesthesia recovery records of all patients were analyzed, and information on disability type, reason for prescribing oral sedatives, prescribed medication and dose, cooperation level during anesthesia induction, anesthesia duration, length of recovery room stay, and complications was retrieved.
Results: A total of 97 patients were identified, of whom 50 and 47 received midazolam and triazolam, respectively. The major types of disability were intellectual disabilities, autism, Down syndrome, blindness, cerebral palsy, and epilepsy. Analyses of changes in cooperation levels after drug administration showed that anesthesia induction without physical restraint was possible in 56.0% of patients in the midazolam group and in 46.8% of patients in the triazolam group (P = 0.312).
Conclusions: With administration of oral midazolam or triazolam, general anesthesia induction without any physical restraint was possible in approximately 50% of patients, with no difference between the drugs.
ISSN
2383-9309
URI
https://hdl.handle.net/10371/200552
DOI
https://doi.org/10.17245/jdapm.2018.18.4.245
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Karm, Myong-Hwan Image

Karm, Myong-Hwan감명환
(기금)조교수
  • School of Dentistry
  • Department of Dentistry
Research Area Dental Anesthesiology, Pain Control, 치과마취, 치과진정법, 통증조절

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