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Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells
DC Field | Value | Language |
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dc.contributor.author | Hong, Eun-Hye | - |
dc.contributor.author | Heo, Eun-Young | - |
dc.contributor.author | Song, Jae-Hyoung | - |
dc.contributor.author | Kwon, Bo-Eun | - |
dc.contributor.author | Lee, Jae-Young | - |
dc.contributor.author | Park, Yaejeong | - |
dc.contributor.author | Kim, Jinwoong | - |
dc.contributor.author | Chang, Sun-Young | - |
dc.contributor.author | Chin, Young Won | - |
dc.contributor.author | Jeon, Sang-Min | - |
dc.contributor.author | Ko, Hyun-Jeong | - |
dc.date.accessioned | 2024-05-02T06:04:28Z | - |
dc.date.available | 2024-05-02T06:04:28Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.citation | Oncotarget, Vol.8 No.25, pp.41401-41411 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://hdl.handle.net/10371/200611 | - |
dc.description.abstract | Trans-Scirpusin A (TSA) is a resveratrol oligomer found in Borassus flabelliferL. We found that TSA inhibited the growth of colorectal cancer Her2/CT26 cells in vivo in mice. Although some cytotoxic T lymphocytes (CTLs) were induced against the tumor-associated antigen Her2, TSA treatment did not significantly increase the level of Her2-specific CTL response compared to that with vehicle treatment. However, there was a significant increase in the level of TNF-a mRNA in tumor tissue and Her2specific Ab (antibody) production. More importantly, we found that TSA overcomes the tumor-associated immunosuppressive microenvironment by reducing the number of CD25+ FoxP3+ regulatory T cells and myeloid-derived suppressor cells (MDSCs). We detected the induction of autophagy in TSA-treated Her2/CT26 cells, based on the increased level of the mammalian autophagy protein LC3 puncta, and increased conversion of LC3-I to LC3-II. Further, TSA induced 5' AMP-activated protein kinase (p-AMPK) (T172) and inhibited mammalian target of rapamycin complex 1 (mTORC1) activity as estimated by phosphorylated ribosomal protein S6 kinase beta-1 (p-p70S6K) levels, thereby suggesting that TSA-mediated AMPK activation and inhibition of mTORC1 pathway might be associated with autophagy induction. TSA also induced apoptosis of Her2/CT26 cells, as inferred by the increased sub-G1 mitotic phases in these cells, Annexin V/PI-double positive results, and TUNELpositive cells. Finally, we found that the combined treatment of mice with docetaxel and TSA successfully inhibited tumor growth to a greater extent than docetaxel alone. Therefore, we propose the use of TSA for supplementary anticancer therapy to support anti-neoplastic drugs, such as docetaxel, by inducing apoptosis in cancer cells and resulting in the induction of neighborhood anti-cancer immunity. | - |
dc.language | 영어 | - |
dc.publisher | Impact Journals | - |
dc.title | Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.18632/oncotarget.17388 | - |
dc.citation.journaltitle | Oncotarget | - |
dc.identifier.wosid | 000404283700118 | - |
dc.identifier.scopusid | 2-s2.0-85020875815 | - |
dc.citation.endpage | 41411 | - |
dc.citation.number | 25 | - |
dc.citation.startpage | 41401 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jinwoong | - |
dc.contributor.affiliatedAuthor | Chin, Young Won | - |
dc.contributor.affiliatedAuthor | Jeon, Sang-Min | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | POLYPHENOLIC COMPOUNDS | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordPlus | DIMER | - |
dc.subject.keywordPlus | TUMORIGENESIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordAuthor | trans-scirpusin A | - |
dc.subject.keywordAuthor | colorectal cancer cells | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | apoptosis | - |
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