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Pin1-mediated modification prolongs the nuclear retention of β-catenin in Wnt3a-induced osteoblast differentiation : Pin1-mediated modification prolongs the nuclear retention of beta-catenin in Wnt3a-induced osteoblast differentiation
DC Field | Value | Language |
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dc.contributor.author | Shin, Hye-Rim | - |
dc.contributor.author | Islam, Rabia | - |
dc.contributor.author | Yoon, Won-Joon | - |
dc.contributor.author | Lee, Taegyung | - |
dc.contributor.author | Cho, Young-Dan | - |
dc.contributor.author | Bae, Han-sol | - |
dc.contributor.author | Kim, Bong-Su | - |
dc.contributor.author | Woo, Kyung-Mi | - |
dc.contributor.author | Baek, Jeong-Hwa | - |
dc.contributor.author | Ryoo, Hyun-Mo | - |
dc.date.accessioned | 2024-05-02T06:05:49Z | - |
dc.date.available | 2024-05-02T06:05:49Z | - |
dc.date.created | 2018-08-27 | - |
dc.date.created | 2018-08-27 | - |
dc.date.created | 2018-08-27 | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | Journal of Biological Chemistry, Vol.291 No.11, pp.5555-5565 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://hdl.handle.net/10371/200634 | - |
dc.description.abstract | The canonical Wnt signaling pathway, in which -catenin nuclear localization is a crucial step, plays an important role in osteoblast differentiation. Pin1, a prolyl isomerase, is also known as a key enzyme in osteogenesis. However, the role of Pin1 in canonical Wnt signal-induced osteoblast differentiation is poorly understood. We found that Pin1 deficiency caused osteopenia and reduction of -catenin in bone lining cells. Similarly, Pin1 knockdown or treatment with Pin1 inhibitors strongly decreased the nuclear -catenin level, TOP flash activity, and expression of bone marker genes induced by canonical Wnt activation and vice versa in Pin1 overexpression. Pin1 interacts directly with and isomerizes -catenin in the nucleus. The isomerized -catenin could not bind to nuclear adenomatous polyposis coli, which drives -catenin out of the nucleus for proteasomal degradation, which consequently increases the retention of -catenin in the nucleus and might explain the decrease of -catenin ubiquitination. These results indicate that Pin1 could be a critical target to modulate -catenin-mediated osteogenesis. | - |
dc.language | 영어 | - |
dc.publisher | American Society for Biochemistry and Molecular Biology Inc. | - |
dc.title | Pin1-mediated modification prolongs the nuclear retention of β-catenin in Wnt3a-induced osteoblast differentiation | - |
dc.title.alternative | Pin1-mediated modification prolongs the nuclear retention of beta-catenin in Wnt3a-induced osteoblast differentiation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1074/jbc.M115.698563 | - |
dc.citation.journaltitle | Journal of Biological Chemistry | - |
dc.identifier.wosid | 000372551800010 | - |
dc.identifier.scopusid | 2-s2.0-84973367105 | - |
dc.citation.endpage | 5565 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 5555 | - |
dc.citation.volume | 291 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Young-Dan | - |
dc.contributor.affiliatedAuthor | Woo, Kyung-Mi | - |
dc.contributor.affiliatedAuthor | Baek, Jeong-Hwa | - |
dc.contributor.affiliatedAuthor | Ryoo, Hyun-Mo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PROLYL ISOMERASE PIN1 | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | WNT/BETA-CATENIN | - |
dc.subject.keywordPlus | SUBCELLULAR-LOCALIZATION | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | MOLECULAR SWITCH | - |
dc.subject.keywordPlus | LEPTOMYCIN-B | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | -catenin | - |
dc.subject.keywordAuthor | cell differentiation | - |
dc.subject.keywordAuthor | nuclear translocation | - |
dc.subject.keywordAuthor | osteoblast | - |
dc.subject.keywordAuthor | Wnt signaling | - |
dc.subject.keywordAuthor | peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) | - |
dc.subject.keywordAuthor | adenomatous polyposis coli (APC) | - |
dc.subject.keywordAuthor | osteogenesis | - |
dc.subject.keywordAuthor | peptidyl prolyl cis-trans isomerization | - |
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