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The volume effect of lidocaine on thoracic epidural anesthesia in conscious Beagle dogs

Cited 13 time in Web of Science Cited 14 time in Scopus
Authors

Son, Won-gyun; Jang, Min; Jo, Sang-min; Yoon, Junghee; Lee, Inhyung

Issue Date
2015-07
Publisher
Blackwell Publishing Inc.
Citation
Veterinary Anaesthesia and Analgesia, Vol.42 No.4, pp.414-424
Abstract
ObjectiveTo evaluate the volume effect of local anesthetic solution on thoracic epidural analgesia in dogs. Study designProspective, experimental trial. AnimalsFive healthy adult Beagle dogs weighing 9.71.3kg. MethodsA catheter was inserted into the seventh thoracic epidural space using a lumbosacral approach, and secured with suture under total intravenous (IV) anesthesia with propofol. Each dog was administered four volume treatments (0.05, 0.10, 0.15 and 0.20mLkg(-1)) of 2% lidocaine via the catheter at 12hour intervals. In every treatment, dogs were re-anesthetized with propofol (6mgkg(-1), IV) and isoflurane, and received iohexol at each volume to visualize the epidural distribution (ED) through computed tomography. Three hours after epidurography, when dogs had recovered from anesthesia, the appropriate volume of lidocaine was injected through the catheter, and sensory blockade (SB) in dermatomes was evaluated by pinching with a mosquito forceps. Results were presented as median (range), and the volume effect on ED and SB was analyzed with one-way Kruskal-Wallis anova. ResultsIn proportion to volumes (0.05, 0.10, 0.15 and 0.20mLkg(-1)), there were significant increases in the extent of ED from 7.4 (5.5-9.0) to 10.4 (8.0-12.0), 13.2 (12.5-13.0), and 15.2 (13.0-18.0) vertebrae, respectively, p<0.001, and in SB from 2.7 (1.0-5.0) to 6.8 (4.5-10.5), 9.9 (6.5-13.0), and 13.1 (11.0-15.0) dermatomes, respectively, p<0.001. Unilateral ED and SB were observed in all treatments with various grades, and this distribution was more frequent in the low volume treatments. In the high volume treatments, temporary complications including Horner's syndrome, ataxia, paraplegia, depression, stupor, and intermittent cough occurred often. Conclusions and clinical relevanceThe increase in volume of local anesthetic solution improved SB by resulting in more consistent bilateral dermatome blockade as well as an extended blockade. However, caution should be exerted, as higher volume injections of lidocaine caused side effects in all dogs.
ISSN
1467-2987
URI
https://hdl.handle.net/10371/201104
DOI
https://doi.org/10.1111/vaa.12232
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  • College of Veterinary Medicine
  • Department of Veterinary Medicine
Research Area Pain Medicine, Systematic Anesthesia, Veterinary Anesthesiology, 수의마취통증의학

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