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Sedative and analgesic effects of intravenous xylazine and tramadol on horses

Cited 35 time in Web of Science Cited 42 time in Scopus

Seo, Jong-pil; Son, Won-gyun; Gang, Sujin; Lee, Inhyung

Issue Date
Journal of Veterinary Science, Vol.12 No.3, pp.281-286
This study was performed to evaluate the sedative and analgesic effects of xylazine (X) and tramadol (T) intravenously (IV) administered to horses. Six thoroughbred saddle horses each received X (1.0 mg/kg), T (2.0 mg/kg), and a combination of XT (1.0 and 2.0 mg/kg, respectively) IV. Heart rate (HR), respiratory rate (RR), rectal temperature (RT), indirect arterial pressure (IAP), capillary refill time (CRT), sedation, and analgesia (using electrical stimulation and pinprick) were measured before and after drug administration. HR and RR significantly decreased from basal values with X and XT treatments, and significantly increased with T treatment (p < 0.05). RT and IAP also significantly increased with T treatment (p < 0.05). CRT did not change significantly with any treatments. The onset of sedation and analgesia were approximately 5 min after both X and XT treatments; however, the XT combination produced a longer duration of sedation and analgesia than X alone. Two horses in the XT treatment group displayed excited transient behavior within 5 min of drug administration. The results suggest that the XT combination is useful for sedation and analgesia in horses. However, careful monitoring for excited behavior shortly after administration is recommended.
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  • College of Veterinary Medicine
  • Department of Veterinary Medicine
Research Area Pain Medicine, Systematic Anesthesia, Veterinary Anesthesiology, 수의마취통증의학


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