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gamma delta T cells regulate the intestinal response to nutrient sensing : γδ T cells regulate the intestinal response to nutrient sensing

Cited 70 time in Web of Science Cited 77 time in Scopus

Sullivan, Zuri A.; Khoury-Hanold, William; Lim, Jaechul; Smillie, Chris; Biton, Moshe; Reis, Bernardo S.; Zwick, Rachel K.; Pope, Scott D.; Israni-Winger, Kavita; Parsa, Roham; Philip, Naomi H.; Rashed, Saleh; Palm, Noah; Wang, Andrew; Mucida, Daniel; Regev, Aviv; Medzhitov, Ruslan

Issue Date
American Association for the Advancement of Science
Science, Vol.371 No.6535, pp.1223-+
The intestine is a site of direct encounter with the external environment and must consequently balance barrier defense with nutrient uptake. To investigate how nutrient uptake is regulated in the small intestine, we tested the effect of diets with different macronutrient compositions on epithelial gene expression. We found that enzymes and transporters required for carbohydrate digestion and absorption were regulated by carbohydrate availability. The "on-demand" induction of this machinery required gamma delta T cells, which regulated this program through the suppression of interleukin-22 production by type 3 innate lymphoid cells. Nutrient availability altered the tissue localization and transcriptome of gamma delta T cells. Additionally, transcriptional responses to diet involved cellular remodeling of the epithelial compartment. Thus, this work identifies a role for gamma delta T cells in nutrient sensing.
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  • College of Veterinary Medicine
  • Department of Veterinary Medicine
Research Area Extreme stress, Local glucocorticoids, Stress adaptation


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