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Discovery of penta-peptides inhibiting activity of formylglycine generating enzyme and its potential antibacterial effect against Mycobacterium tuberculosis : The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against <i>Mycobacterium tuberculosis</i>
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Asiimwe, Nicholas | - |
dc.contributor.author | Al Mazid, Mohammad Faysal | - |
dc.contributor.author | Jeong, Yong Taek | - |
dc.contributor.author | Lee, Ju Yong | - |
dc.contributor.author | Lee, Jun Seok | - |
dc.date.accessioned | 2024-05-13T04:59:41Z | - |
dc.date.available | 2024-05-13T04:59:41Z | - |
dc.date.created | 2024-05-13 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | RSC Advances, Vol.12 No.29, pp.18884-18888 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201504 | - |
dc.description.abstract | The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit peptides. In addition, the lead peptides also showed potential antibacterial effects in a Mycobacterium tuberculosis model. | - |
dc.language | 영어 | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | Discovery of penta-peptides inhibiting activity of formylglycine generating enzyme and its potential antibacterial effect against Mycobacterium tuberculosis | - |
dc.title.alternative | The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/d2ra03379h | - |
dc.citation.journaltitle | RSC Advances | - |
dc.identifier.wosid | 000818027200001 | - |
dc.identifier.scopusid | 2-s2.0-85134341828 | - |
dc.citation.endpage | 18888 | - |
dc.citation.number | 29 | - |
dc.citation.startpage | 18884 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Ju Yong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | SULFATASES | - |
dc.subject.keywordPlus | INTERFACE | - |
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- Graduate School of Convergence Science & Technology
- Dept. of Molecular and Biopharmaceutical Sciences
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