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Hb-adjusted DLCO with GLI reference predicts long-term survival after HSCT in children
DC Field | Value | Language |
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dc.contributor.author | Lee, Hye Jin | - |
dc.contributor.author | Kim, Kyunghoon | - |
dc.contributor.author | Kim, Seong Koo | - |
dc.contributor.author | Lee, Jae Wook | - |
dc.contributor.author | Yoon, Jong-seo | - |
dc.contributor.author | Chung, Nack-Gyun | - |
dc.contributor.author | Bin, Cho | - |
dc.date.accessioned | 2024-05-13T07:33:00Z | - |
dc.date.available | 2024-05-13T07:33:00Z | - |
dc.date.created | 2023-05-08 | - |
dc.date.created | 2023-05-08 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | Bone Marrow Transplantation, Vol.56 No.8, pp.1929-1936 | - |
dc.identifier.issn | 0268-3369 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201606 | - |
dc.description.abstract | This study aimed to evaluate the pretransplant diffusing capacity as a predictor of outcomes in pediatric allogeneic hematopoietic stem cell transplantation (allo-HSCT). Retrospective cohort study of 176 children followed outcomes for 5 years after allo-HSCT. We conducted an analysis of PFTs include spirometry, body plethysmography, and diffusing capacity prior to allo-HSCT. We analyzed the probabilities of overall survival (OS), disease-related mortality (DRM), and non-relapse mortality (NRM). Of all carbon monoxide diffusing capacity (DLCO) parameters obtained using the Global Lung Function Initiative (GLI)-2017, univariate analysis showed that the grade 3, 4 of DLCOadj and Category III, IV of LFS significantly increase NRM (p = 0.003 and p = 0.008). Multivariate analysis indicated that a significant increase in the risk of NRM is associated with grades 3, 4 DLCOadj (hazard ratio [HR] = 4.90, p = 0.020). Kaplan-Meier analyses showed that a significant stepwise increase in NRM was observed with both worse pretransplant DLCOadj grades and LFS categories (p < 0.001 and p = 0.003). A compromised pretransplant diffusing capacity and a high LFS significantly increase the risk of NRM. Especially, DLCOadj before transplantation can be used as an important predictor of NRM after allo-HSCT in children with malignancy. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Hb-adjusted DLCO with GLI reference predicts long-term survival after HSCT in children | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41409-020-01202-9 | - |
dc.citation.journaltitle | Bone Marrow Transplantation | - |
dc.identifier.wosid | 000634709700003 | - |
dc.identifier.scopusid | 2-s2.0-85103282900 | - |
dc.citation.endpage | 1936 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 1929 | - |
dc.citation.volume | 56 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Kyunghoon | - |
dc.description.journalClass | 1 | - |
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