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Risk factors for the discontinuation of roflumilast in patients with chronic obstructive pulmonary disease

Cited 13 time in Web of Science Cited 13 time in Scopus
Authors

Kim, Kyung Hoon; Kang, Hye Seon; Kim, Ju Sang; Yoon, Hyoung Kyu; Kim, Sung Kyoung; Rhee, Chin Kook

Issue Date
2017-12
Publisher
Dove Medical Press Ltd
Citation
International Journal of COPD, Vol.12, pp.3449-3456
Abstract
Introduction: Roflumilast is a phosphodiesterase-4 inhibitor, which can decrease exacerbation in patients with chronic obstructive pulmonary disease (COPD). However, adverse effects are a major barrier to medication use, and little is known regarding the risk factors for discontinuation of roflumilast in COPD patients. Method: A search of the clinical databases identified all patients who were prescribed roflumilast between December 2012 and April 2015 in the four hospitals of The Catholic University of Korea, Korea. The study subjects were limited to patients who had taken 500 µg of roflumilast. We studied the factors associated with drug discontinuation and drug adverse events by univariate and multivariate analyses. Results: Among 154 eligible patients, 54 (35.1%) discontinued their roflumilast prescription. Most patients were elderly, male, current or former smokers, and had moderate-to-severe airflow limitation. Low-body mass index (BMI) patients were more likely to undergo drug discontinuation (1-unit decrease in BMI: odds ratio [OR] =1.165, p=0.006; BMI <23 kg/m2: OR =2.960, p=0.004). Fifty-five patients (35.7%) had adverse events. Loss of appetite, diarrhea, nausea, headache, and weight loss were the most frequent adverse events. Low-BMI patients were more likely to experience adverse events (1-unit decrease in BMI: OR =1.151, p=0.010; BMI <23 kg/m2: OR =2.644, p=0.009). Conclusions: The patient discontinuation and adverse events rates in this study were higher than in previous randomized controlled studies. Discontinuation of roflumilast in ethnic Koreans is more likely to occur in low-BMI patients. In a clinical setting, low-BMI patients can more easily discontinue roflumilast; clinicians should, therefore, provide greater care for these patients.
ISSN
1176-9106
URI
https://hdl.handle.net/10371/201621
DOI
https://doi.org/10.2147/COPD.S143967
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  • College of Medicine
  • Department of Medicine
Research Area 식품알레르기, 아토피피부염, 천식

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