Publications

Detailed Information

Low-dose RaDiation therapy for patients with KNee osteoArthritis (LoRD-KNeA): a protocol for a sham-controlled randomised trial

Cited 1 time in Web of Science Cited 1 time in Scopus
Authors

Kim, Byoung Hyuck; Shin, Kichul; Kim, Min Jung; Kim, Hak Jae; Ro, Du Hyun; Wang, Joon Ho; Lee, Dae-Hee; Kim, Dong Hyun; Sun, Jiyu; Lee, Ji Hyun; Kim, Ji Young; Hong, Eun-Hee; Cho, Seong-Jun; Han, Hyuk-Soo; Park, Won

Issue Date
2023-02
Publisher
BMJ Publishing Group
Citation
BMJ Open, Vol.13 No.2, p. 069691
Abstract
Introduction Low-dose radiation therapy (LDRT) for osteoarthritis (OA) has been performed for several decades. However, supporting evidence from randomised studies using modern methodologies is lacking, and a recently published randomised study failed to show the significant benefit of LDRT. The presented trial aims to evaluate the efficacy and safety of LDRT for patients with knee OA.Methods and analysis This prospective, multicentre, randomised trial will be conducted in the Republic of Korea. A total of 114 participants will be randomly assigned (1:1:1) to receive sham irradiation, 0.3 Gy/6 fractions of LDRT or 3 Gy/6 fractions of LDRT. Key inclusion criteria are primary knee OA with Kellgren-Lawrence grade 2-3 and visual analogue scale 50-90 when walking at the baseline. The primary endpoint is the rate of responders at 4 months after LDRT according to the OARSI-OMERACT criteria. Concomitant use of analgesics is prohibited until the primary efficacy evaluation is scheduled.Ethics and dissemination Currently, approval from the Ministry of Food and Drug Safety of the Republic of Korea and the institutional review board of each participating hospital has been obtained. Patient enrolment began in October 2022 and is ongoing at three participating sites. The results will be disseminated to academic audiences and the public via publication in an international peer-reviewed journal and presentation at conferences. This trial will provide valuable information on the safety and efficacy of LDRT for patients with knee OA.
ISSN
2044-6055
URI
https://hdl.handle.net/10371/201642
DOI
https://doi.org/10.1136/bmjopen-2022-069691
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

Kim, Byoung hyuck Image

Kim, Byoung hyuck김병혁
(기금)조교수
  • College of Medicine
  • Department of Medicine
Research Area 소화기암, 육종, 폐암

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share