Detailed Information

Role of adjuvant chemoradiotherapy and chemotherapy in patients with resected gallbladder carcinoma: a multi-institutional analysis (KROG 19-04)

Cited 2 time in Web of Science Cited 3 time in Scopus

Lee, Sung Uk; Seong, Jinsil; Kim, Tae Hyun; Im, Jung Ho; Kim, Woo Chul; Kim, Kyubo; Park, Hae Jin; Kim, Tae Gyu; Kim, Youngkyong; Jeong, Bae Kwon; Kim, Jin Hee; Kim, Byoung Hyuck; Nam, Taek-Keun

Issue Date
Chinese Anticancer Association
Cancer Biology and Medicine, Vol.19 No.6, pp.931-944
Objective: The effectiveness of adjuvant treatments for resected gallbladder carcinoma (GBC) has remained unclear due to lack of randomized controlled trials; thus, the aim of present study was to evaluate the role of adjuvant treatments, including chemoradiotherapy (CRT) and/or chemotherapy (CTx), in patients with resected GBC. Methods: A total of 733 GBC patients who received curative-intent surgical resection were identified in a multi-institutional database. Of 733 patients, 372 (50.8%) did not receive adjuvant treatment, whereas 215 (29.3%) and 146 (19.9%) received adjuvant CTx and CRT, respectively. The locoregional recurrence-free survival (LRFS), recurrence-free survival (RFS), and overall survival (OS) of the adjuvant treatment groups were compared according to tumor stage (stage II vs. stage III–IV). Results: In stage II disease (n = 381), the 5-year LRFS, RFS, and OS were not significantly different among the no-adjuvant therapy, CTx, and CRT groups, and positive resection margin, presence of perineural invasion, and Nx classification were consistently associated with worse LRFS, RFS, and OS in the multivariate analysis (P < 0.05). For stage III–IV (n = 352), the CRT group had significantly higher 5-year LRFS, RFS, and OS than the no-adjuvant therapy and CTx groups (67.8%, 45.2%, and 56.9%; 37.9%, 28.8%, and 35.4%; and 45.0%, 30.0%, and 45.7%, respectively) (P < 0.05). Conclusions: CRT has value as adjuvant treatment for resected GBC with stage III–IV disease. Further study is needed for stage II disease with high-risk features.
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

Kim, Byoung hyuck Image

Kim, Byoung hyuck김병혁
  • College of Medicine
  • Department of Medicine
Research Area 소화기암, 육종, 폐암


Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.