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Clinical significance of radiation dose-volume parameters and functional status on the patient-reported quality of life changes after thoracic radiotherapy for lung cancer: a prospective study
DC Field | Value | Language |
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dc.contributor.author | Kim, Byoung Hyuck | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Kim, Ki Hwan | - |
dc.contributor.author | Moon, Hyeon Jong | - |
dc.contributor.author | Kim, Suzy | - |
dc.date.accessioned | 2024-05-14T01:26:47Z | - |
dc.date.available | 2024-05-14T01:26:47Z | - |
dc.date.created | 2021-08-20 | - |
dc.date.created | 2021-08-20 | - |
dc.date.created | 2021-08-20 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | Radiologia Medica, Vol.126 No.3, pp.466-473 | - |
dc.identifier.issn | 0033-8362 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201655 | - |
dc.description.abstract | Purpose To date, limited data exist about the relationship between radiation dose-volume parameters and patient-reported quality of life (QOL) after thoracic radiotherapy (RT) for lung cancer. We conducted this prospective study to investigate which clinico-dosimetric factors have an impact on functional declines and symptom developments after thoracic RT for lung cancer. Materials and methods The study included 44 patients who had underwent thoracic three-dimensional conformal RT at our institution from 2016 to 2017. The health-related QOL was assessed using the EORTC QLQ-C30 and QLQ-LC13 questionnaires before RT (preRT), at the end of RT (endRT), and 3, 6, and 12 months after the completion of RT. RT dose-volume parameters of adjacent normal organs such as the lung, heart, and esophagus were retrieved and used for regression analysis. Results Thoracic RT induced a temporary deterioration of many of the functional statuses and symptoms, but most of those improved and recovered to baseline levels 3 months after RT. However, the role function (RF) decline persisted until 6 months after RT (p < 0.05). Dysphagia showed the most noticeable change at the endRT (p < 0.001). In the multiple regression analysis, the absolute volume of body received at least 50 Gy (p = 0.021) and a preRT RF score (p = 0.001) was significantly associated with the endRT RF scores. Dysphagia at the endRT was significantly associated with the V40 of the esophagus (p = 0.047), preRT emotional function (p = 0.029), and receipt of concurrent chemotherapy (p = 0.022). Conclusions Both the dosimetric parameters and preRT functional status have an impact on the weak aspect of patient-reported QOL, which may cause poor treatment compliance during and after thoracic RT. For patients with a low preRT QOL score or those having large tumor which may result in higher dose volumes, careful RT planning could prevent the deterioration of QOL after RT. | - |
dc.language | 영어 | - |
dc.publisher | Edizioni Minerva Medica | - |
dc.title | Clinical significance of radiation dose-volume parameters and functional status on the patient-reported quality of life changes after thoracic radiotherapy for lung cancer: a prospective study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s11547-020-01273-0 | - |
dc.citation.journaltitle | Radiologia Medica | - |
dc.identifier.wosid | 000566293200002 | - |
dc.identifier.scopusid | 2-s2.0-85090222943 | - |
dc.citation.endpage | 473 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 466 | - |
dc.citation.volume | 126 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byoung Hyuck | - |
dc.contributor.affiliatedAuthor | Kim, Suzy | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | DYSPHAGIA | - |
dc.subject.keywordPlus | QLQ-C30 | - |
dc.subject.keywordAuthor | Lung neoplasms | - |
dc.subject.keywordAuthor | Radiotherapy | - |
dc.subject.keywordAuthor | Quality of life | - |
dc.subject.keywordAuthor | Dosimetric parameters | - |
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