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Heart substructural dosimetric parameters and risk of cardiac events after definitive chemoradiotherapy for stage III non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Jang, Bum-Sup | - |
dc.contributor.author | Cha, Myung-Jin | - |
dc.contributor.author | Kim, Hak Jae | - |
dc.contributor.author | Oh, Seil | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Kim, Eunji | - |
dc.contributor.author | Kim, Byoung Hyuck | - |
dc.contributor.author | Kim, Jae Sik | - |
dc.contributor.author | Chang, Ji Hyun | - |
dc.date.accessioned | 2024-05-14T01:26:50Z | - |
dc.date.available | 2024-05-14T01:26:50Z | - |
dc.date.created | 2021-03-04 | - |
dc.date.created | 2021-03-04 | - |
dc.date.created | 2021-03-04 | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | Radiotherapy and Oncology, Vol.152, pp.126-132 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201656 | - |
dc.description.abstract | Introduction: We evaluated the incidence of cardiac events after chemoradiotherapy in patients with stage III non-small cell lung cancer (NSCLC) based on baseline cardiovascular risk and the heart substructures' radiation dose. Methods: From 2008 to 2018, the cardiac events of 258 patients with stage III NSCLC who received definitive chemoradiotherapy were reviewed. The 10-year cardiovascular risk was calculated using the Atherosclerotic Cardiovascular Disease (ASCVD) scoring system. Dose-volume histograms were estimated for each cardiac chamber. A multivariate competing-risk regression analysis was conducted to assess each cardiac event's subhazard function (SHR). Results: The median follow-up was 27.5 months overall and 38.9 months for survivors. Among the 179 deaths, none was definitely related to cardiac conditions. Altogether, 32 cardiovascular events affected 27 patients (10.5%) after chemoradiotherapy. Ten were major cardiac adverse events, including heart failure (N = 6) and acute coronary syndrome (ACS, N = 4). Most cardiovascular events were related to well-known risk factors. However, the volume percentage of the left ventricle (LV) receiving 60 Gy (LV V60) > 0 was significantly associated with ACS (SHR = 9.49, 95% CI = 1.28-70.53, P = 0.028). In patients with high cardiovascular risk (ASCVD score > 7.5%), LV V60 > 0% remained a negative ACS prognostic factor (P = 0.003). Meanwhile, in patients with low cardiovascular risk, the LV radiation dose was not associated with ACS events (P = 0.242). Conclusions: A high LV radiation dose could increase ACS events in patients with stage III NSCLC and high cardiovascular risk. Pre-treatment cardiac risk evaluation and individualized surveillance may help prevent cardiac events after chemoradiotherapy. (C) 2020 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Heart substructural dosimetric parameters and risk of cardiac events after definitive chemoradiotherapy for stage III non-small cell lung cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.radonc.2020.09.050 | - |
dc.citation.journaltitle | Radiotherapy and Oncology | - |
dc.identifier.wosid | 000594802900021 | - |
dc.identifier.scopusid | 2-s2.0-85094574898 | - |
dc.citation.endpage | 132 | - |
dc.citation.startpage | 126 | - |
dc.citation.volume | 152 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hak Jae | - |
dc.contributor.affiliatedAuthor | Oh, Seil | - |
dc.contributor.affiliatedAuthor | Wu, Hong-Gyun | - |
dc.contributor.affiliatedAuthor | Kim, Byoung Hyuck | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ASSOCIATION TASK-FORCE | - |
dc.subject.keywordPlus | DOSE-ESCALATION TRIALS | - |
dc.subject.keywordPlus | AMERICAN-COLLEGE | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordAuthor | Chemoradiotherapy | - |
dc.subject.keywordAuthor | Cardiac event | - |
dc.subject.keywordAuthor | Dosimetry | - |
dc.subject.keywordAuthor | Heart substructure | - |
dc.subject.keywordAuthor | Lung cancer | - |
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