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The Role of Adjuvant Chemoradiotherapy in Nonhilar Extrahepatic Bile Duct Cancer: A Long-Term Single-Institution Analysis
DC Field | Value | Language |
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dc.contributor.author | Chang, Won Ick | - |
dc.contributor.author | Kim, Byoung Hyuck | - |
dc.contributor.author | Kang, Hyun-Cheol | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Kim, Hongbeom | - |
dc.contributor.author | Kwon, Wooil | - |
dc.contributor.author | Jang, Jin-Young | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.date.accessioned | 2024-05-14T01:35:03Z | - |
dc.date.available | 2024-05-14T01:35:03Z | - |
dc.date.created | 2021-10-19 | - |
dc.date.created | 2021-10-19 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.citation | International Journal of Radiation Oncology Biology Physics, Vol.111 No.2, pp.395-404 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201689 | - |
dc.description.abstract | Purpose: Despite frequent use in the clinical setting, especially for patients with high-risk factors for relapse, the role of adju-vant treatment has not been clarified in nonhilar extrahepatic bile duct cancer (NH-EHBDC). The goal of this study is to iden-tify the role of adjuvant chemoradiotherapy (CRT) in NH-EHBDC patients after radical surgery. Methods and Materials: Patients with NH-EHBDC who underwent radical surgery from July 2007 to December 2018 were reviewed retrospectively. Univariate and multivariate analyses were conducted to identify prognostic factors for locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS), disease-free survival (DFS), and overall survival (OS). Subgroup analyses were performed to further identify the role of adjuvant CRT. Results: Three hundred twenty-eight patients were accrued. At a median follow-up of 37.1 months (range, 1.0-144.2 months), the 3-year LRRFS, DMFS, DFS, and OS were 63.4%, 59.0%, 53.2%, and 67.5%, respectively. In multivariate analysis, adjuvant CRT was an independent prognostic factor for LRRFS, DMFS, DFS, and OS (P < .05). For patients with nodal involvement, pT3 stage, tumor size > >= 5 cm, poorly differentiated tumor, and R1 resection, adjuvant CRT significantly improved DFS (P < .05). Conclusions: In patients with NH-EHBDC, adjuvant CRT significantly improved LRRFS and DFS. For patients with risk fac-tors such as nodal involvement, pT3 stage, poorly differentiated tumor, tumor size >= 5 cm, or R1 resection, adjuvant CRT might contribute to improve treatment outcomes. (C) 2021 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | The Role of Adjuvant Chemoradiotherapy in Nonhilar Extrahepatic Bile Duct Cancer: A Long-Term Single-Institution Analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijrobp.2021.05.012 | - |
dc.citation.journaltitle | International Journal of Radiation Oncology Biology Physics | - |
dc.identifier.wosid | 000701877700014 | - |
dc.identifier.scopusid | 2-s2.0-85108643721 | - |
dc.citation.endpage | 404 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 395 | - |
dc.citation.volume | 111 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byoung Hyuck | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Kim, Hongbeom | - |
dc.contributor.affiliatedAuthor | Jang, Jin-Young | - |
dc.contributor.affiliatedAuthor | Chie, Eui Kyu | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DISTAL CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | CURATIVE RESECTION | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | CHEMORADIATION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | EXPERIENCE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | LOCATION | - |
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