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Identifying long-term survival candidates among patients with isolated locoregionally recurrent breast cancer: Implications of the use of systemic chemotherapy

DC Field Value Language
dc.contributor.authorKim, Byoung Hyuck-
dc.contributor.authorShin, Kyung Hwan-
dc.contributor.authorChie, Eui Kyu-
dc.contributor.authorKim, Jin Ho-
dc.contributor.authorKim, Kyubo-
dc.contributor.authorHwang, Ki-Tae-
dc.contributor.authorKim, Jongjin-
dc.contributor.authorChoi, In Sil-
dc.contributor.authorPark, Jin Hyun-
dc.contributor.authorKim, Suzy-
dc.date.accessioned2024-05-14T01:35:27Z-
dc.date.available2024-05-14T01:35:27Z-
dc.date.created2020-07-13-
dc.date.created2020-07-13-
dc.date.issued2020-06-
dc.identifier.citationJournal of Breast Cancer, Vol.23 No.3, pp.279-290-
dc.identifier.issn1738-6756-
dc.identifier.urihttps://hdl.handle.net/10371/201696-
dc.description.abstractPurpose: We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Methods: We analyzed 125 patients who underwent salvage local treatments for ILRR after initial curative breast surgery. Results: Fifty-two (41.6%) patients experienced secondary recurrence or disease progression, of which 20 (38.5%) experienced a secondary locoregional recurrence and 40 (76.9%) experienced DM as the first site of failure. In multivariate analysis of distant metastasis free survival (DMFS) and post-recurrence OS, the initial pN2-3 stage, a disease-free interval of < 36 months, and non-curative resection for recurrent disease were independently poor prognosticators. The score for patients stratified according to the number of risk factors increased from 0 to 3; the corresponding 5-year DMFS rates were 91.4%, 53.0%, 35.9%, and 0% and the 5-year OS rates were 97.3%, 70.4%, 32.7%, and 25.0%, respectively (p < 0.001). Systemic chemotherapy reduced DM in patients with a score of 2-3, but it did not in those with a score of 0-1. Conclusion: Our collective stratification can help with prognosis prediction for ILRR of breast cancer. Depending on the DM risk of patients, the potential combination of systemic therapy should be discussed further.-
dc.language영어-
dc.publisher한국유방암학회-
dc.titleIdentifying long-term survival candidates among patients with isolated locoregionally recurrent breast cancer: Implications of the use of systemic chemotherapy-
dc.typeArticle-
dc.identifier.doi10.4048/jbc.2020.23.e31-
dc.citation.journaltitleJournal of Breast Cancer-
dc.identifier.wosid000543376900005-
dc.identifier.scopusid2-s2.0-85086843108-
dc.citation.endpage290-
dc.citation.number3-
dc.citation.startpage279-
dc.citation.volume23-
dc.identifier.kciidART002595655-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorKim, Byoung Hyuck-
dc.contributor.affiliatedAuthorShin, Kyung Hwan-
dc.contributor.affiliatedAuthorChie, Eui Kyu-
dc.contributor.affiliatedAuthorKim, Jin Ho-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusTUMOR RECURRENCE-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusPROGNOSIS-
dc.subject.keywordPlusREIRRADIATION-
dc.subject.keywordPlusRADIOTHERAPY-
dc.subject.keywordPlusCARCINOMA-
dc.subject.keywordPlusCALOR-
dc.subject.keywordAuthorBreast neoplasm-
dc.subject.keywordAuthorNeoplasm recurrence-
dc.subject.keywordAuthorLocal-
dc.subject.keywordAuthorRisk factors-
dc.subject.keywordAuthorSurvivors-
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Kim, Byoung hyuck김병혁
(기금)조교수
  • College of Medicine
  • Department of Medicine
Research Area 소화기암, 육종, 폐암

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