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Identifying long-term survival candidates among patients with isolated locoregionally recurrent breast cancer: Implications of the use of systemic chemotherapy
DC Field | Value | Language |
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dc.contributor.author | Kim, Byoung Hyuck | - |
dc.contributor.author | Shin, Kyung Hwan | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.contributor.author | Kim, Jin Ho | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Hwang, Ki-Tae | - |
dc.contributor.author | Kim, Jongjin | - |
dc.contributor.author | Choi, In Sil | - |
dc.contributor.author | Park, Jin Hyun | - |
dc.contributor.author | Kim, Suzy | - |
dc.date.accessioned | 2024-05-14T01:35:27Z | - |
dc.date.available | 2024-05-14T01:35:27Z | - |
dc.date.created | 2020-07-13 | - |
dc.date.created | 2020-07-13 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | Journal of Breast Cancer, Vol.23 No.3, pp.279-290 | - |
dc.identifier.issn | 1738-6756 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201696 | - |
dc.description.abstract | Purpose: We aimed to investigate the clinicopathologic factors associated with distant metastasis (DM) and post-recurrence overall survival (OS) after salvage treatments for isolated locoregional recurrence (ILRR) of breast cancer and identify long-term surviving patients for providing a more personalized therapy. Methods: We analyzed 125 patients who underwent salvage local treatments for ILRR after initial curative breast surgery. Results: Fifty-two (41.6%) patients experienced secondary recurrence or disease progression, of which 20 (38.5%) experienced a secondary locoregional recurrence and 40 (76.9%) experienced DM as the first site of failure. In multivariate analysis of distant metastasis free survival (DMFS) and post-recurrence OS, the initial pN2-3 stage, a disease-free interval of < 36 months, and non-curative resection for recurrent disease were independently poor prognosticators. The score for patients stratified according to the number of risk factors increased from 0 to 3; the corresponding 5-year DMFS rates were 91.4%, 53.0%, 35.9%, and 0% and the 5-year OS rates were 97.3%, 70.4%, 32.7%, and 25.0%, respectively (p < 0.001). Systemic chemotherapy reduced DM in patients with a score of 2-3, but it did not in those with a score of 0-1. Conclusion: Our collective stratification can help with prognosis prediction for ILRR of breast cancer. Depending on the DM risk of patients, the potential combination of systemic therapy should be discussed further. | - |
dc.language | 영어 | - |
dc.publisher | 한국유방암학회 | - |
dc.title | Identifying long-term survival candidates among patients with isolated locoregionally recurrent breast cancer: Implications of the use of systemic chemotherapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.4048/jbc.2020.23.e31 | - |
dc.citation.journaltitle | Journal of Breast Cancer | - |
dc.identifier.wosid | 000543376900005 | - |
dc.identifier.scopusid | 2-s2.0-85086843108 | - |
dc.citation.endpage | 290 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 279 | - |
dc.citation.volume | 23 | - |
dc.identifier.kciid | ART002595655 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Byoung Hyuck | - |
dc.contributor.affiliatedAuthor | Shin, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | Chie, Eui Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Jin Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR RECURRENCE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | REIRRADIATION | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | CALOR | - |
dc.subject.keywordAuthor | Breast neoplasm | - |
dc.subject.keywordAuthor | Neoplasm recurrence | - |
dc.subject.keywordAuthor | Local | - |
dc.subject.keywordAuthor | Risk factors | - |
dc.subject.keywordAuthor | Survivors | - |
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