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Validating the ACOSOG Z0011 trial result: A population-based study using the SEER database

Cited 10 time in Web of Science Cited 12 time in Scopus
Authors

Jung, Jiwoong; Kim, Byoung Hyuck; Kim, Jongjin; Oh, Sohee; Kim, Su-jin; Lim, Chang-Sup; Choi, In Sil; Hwang, Ki-Tae

Issue Date
2020-04
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Citation
Cancers, Vol.12 No.4, p. 950
Abstract
The Z0011 trial demonstrated that axillary lymph node dissection (ALND) could be omitted in spite of 1-2 metastatic sentinel lymph nodes. This study aimed to validate the results on a population-based database. The Surveillance, Epidemiology, and End Results (SEER) database was searched for patients comparable to the Z0011 participants. The type of axillary surgery was estimated using the total number of examined axillary lymph nodes (ALNs). Breast cancer-specific mortality (BCSM) was compared between patients with >= 10 ALNs (the sentinel lymph node dissection (SLND) and ALND group, or "SLND + ALND group") and patients with one or two ALNs (the "SLND group"). During 2010-2015, the SEER database included 7077 and 6620 patients categorized in the SLND group and the SLND + ALND group, respectively. Death was observed for 515 patients (7.3%) in the SLND group and 589 patients (8.9%) in the SLND + ALND group based on a median follow-up of 41 months. After propensity-score matching, the adjusted hazard ratio for BCSM in the SLND group (vs. the SLND + ALND group) was 1.038 (95% confidence interval: 0.798-1.350). Regardless of the SLND criteria, the outcomes were not significantly different between the two groups. This retrospective cohort study of Z0011-comparable patients revealed that ALND could be omitted based on the Z0011 strategy, even among patients with <= 2 dissected ALNs.
ISSN
2072-6694
URI
https://hdl.handle.net/10371/201697
DOI
https://doi.org/10.3390/cancers12040950
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Kim, Byoung hyuck김병혁
(기금)조교수
  • College of Medicine
  • Department of Medicine
Research Area 소화기암, 육종, 폐암

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