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Clinical outcomes of isolated regional lymph node recurrence in patients with malignant cutaneous melanoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Jeanny | - |
dc.contributor.author | Kim, Young A. | - |
dc.contributor.author | Lee, Cheol | - |
dc.contributor.author | Kim, Byoung Hyuck | - |
dc.contributor.author | Kim, Suzy | - |
dc.contributor.author | Kim, Il Han | - |
dc.date.accessioned | 2024-05-14T01:35:44Z | - |
dc.date.available | 2024-05-14T01:35:44Z | - |
dc.date.created | 2019-11-29 | - |
dc.date.created | 2019-11-29 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.citation | Anticancer Research, Vol.39 No.6, pp.3147-3157 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201701 | - |
dc.description.abstract | Background/Aim: Regional lymph node recurrence (RLNR) is the most common pattern of recurrence within 2 years from the diagnosis of patients with non-metastatic malignant cutaneous melanoma. However, isolated RLNR without distant metastasis has been rarely studied. Patients and Methods: Forty patients with isolated RLNR as a first recurrence were analyzed retrospectively. The clinical outcomes and prognostic impact of clinicopathologic parameters were analyzed. Immunostaining for FOXP3, VEGF, pAKT, and pS6 was also performed. Results: The median disease-free interval from first diagnosis to isolated RLNR and post-recurrence recurrence-free survival (pRFS) were 12 months and 7.2 months, respectively. Distant failure was the most common pattern of failure after isolated RLNR (67.5%). The number of initially harvested lymph nodes (LN) >7 and LN ratio >22.2% at the time of recurrence were prognosticators for pRFS in multivariate analysis. None of the tested biomarkers were significantly related to prognosis. The 5-year post-recurrence overall survival rate was 84.9%. Conclusion: Most patients with isolated RLNR will experience a second failure within months, especially distantly. The number of initially harvested LNs and LN ratio at the time of recurrence could predict pRFS. | - |
dc.language | 영어 | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.title | Clinical outcomes of isolated regional lymph node recurrence in patients with malignant cutaneous melanoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.21873/anticanres.13452 | - |
dc.citation.journaltitle | Anticancer Research | - |
dc.identifier.wosid | 000470666800040 | - |
dc.identifier.scopusid | 2-s2.0-85067540440 | - |
dc.citation.endpage | 3157 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 3147 | - |
dc.citation.volume | 39 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byoung Hyuck | - |
dc.contributor.affiliatedAuthor | Kim, Il Han | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | SERUM VEGF | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | HIGH-RISK | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | RATIO | - |
dc.subject.keywordPlus | LYMPHADENECTOMY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BIOPSY | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordAuthor | Melanoma | - |
dc.subject.keywordAuthor | lymph node | - |
dc.subject.keywordAuthor | recurrence | - |
dc.subject.keywordAuthor | lymph node ratio | - |
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