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Cost-Effectiveness Comparison of Genechip and Conventional Drug Susceptibility Test for Detecting Multidrug-Resistant Tuberculosis in China

Cited 11 time in Web of Science Cited 16 time in Scopus
Authors

Pang, Yu; Li, Qiang; Ou, Xichao; Sohn, Hojoon; Zhang, Zhiying; Li, Junchen; Xia, Hui; Kam, Kai Man; O'Brien, Richard J.; Chi, Junying; Huan, Shitong; Chin, Daniel P.; Zhao, Yan-lin

Issue Date
2013-07
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, Vol.8 No.7
Abstract
Background: Genechip (CapitalBio, Beijing, China) is a system for diagnosing resistance to rifampin and isoniazid, which shows high efficiency in detecting drug-resistant tuberculosis. Here, we firstly evaluated the costs of Genechip for detecting the drug susceptibility of Mycobacterium tuberculosis, compared to conventional drug susceptibility test (DST) in laboratories in China. Methodology/Principal Findings: Data on the costs of the two tests were collected at four hospitals. Costs were calculated using the essential factor cost calculation method. The costs of diagnosing a single case of multidrug-resistant tuberculosis (MDR-TB) using Genechip and DST were US$22.38 and $53.03, respectively. Taking into account the effect on costs from failure of a certain number of tests to accurately diagnose MDR-TB, the costs of Genechip and DST increased by 17.65% and 5.22%, respectively. The cost of both tests decreased with the increasing prevalence of MDR-TB disease, and the cost of Genechip at a sensitivity of more than 50% was lower than that of DST. When price of Genechip was varied to 50%, 80%, 150%, and 200% of the original price, the cost of Genechip at sensitivities of more than 30%, 40%, 60%, and 70%, respectively, was also lower than that of DST. Conclusions/Significance: This study showed that Genechip was a more cost-effective method of diagnosing MDR-TB compared to conventional DST.
ISSN
1932-6203
URI
https://hdl.handle.net/10371/201770
DOI
https://doi.org/10.1371/journal.pone.0069267
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  • College of Medicine
  • Department of Human Systems Medicine
Research Area 결핵, 국제보건, 에이즈

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