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Chemoselective tyrosine bioconjugation through sulfate click reaction

Cited 30 time in Web of Science Cited 31 time in Scopus
Authors

Choi, Eun Joung; Jung, Dongwook; Kim, Jong-Seo; Lee, Yan; Kim, B. Moon

Issue Date
2018-08-01
Publisher
John Wiley & Sons Ltd.
Citation
Chemistry - A European Journal, Vol.24 No.43, pp.10948-10952
Abstract
A novel and selective tyrosine functionalization strategy through SuFEx (sulfur fluoride exchange) chemistry is presented. In this approach, free tyrosine (Tyr) reacts selectively with aryl fluorosulfate in the presence of various nucleophilic amino acid residues in bio-tolerable conditions. Chemoselectivity of this unique SuFEx reaction was confirmed in amino acid, peptide, and protein conjugations. The functions of peptides and proteins were well-preserved as demonstrated from the Tyr-specific modification of cell-penetrating peptide and erythropoietin. This method is well-suited for residue-specific modification of native proteins, and thus would expand the versatility of bio-conjugation in protein chemistry.
ISSN
0947-6539
URI
https://hdl.handle.net/10371/201891
DOI
https://doi.org/10.1002/chem.201802380
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  • College of Natural Sciences
  • School of Biological Sciences
Research Area Molecular Interactomics, Proteomics, Systems Biology, 단백체학, 분자상호작용체학, 시스템생물학

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