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Stereoselective synthesis of (+)-SCH 351448: A unique ligand system for sodium, calcium, and other cations
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, EJ | - |
dc.contributor.author | Cho, EJ | - |
dc.contributor.author | Ji, MK | - |
dc.contributor.author | Lee, YE | - |
dc.contributor.author | Shin, DM | - |
dc.contributor.author | Choi, SY | - |
dc.contributor.author | Chung, YK | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Kim, HJ | - |
dc.contributor.author | Lee, SG | - |
dc.contributor.author | Lah, MS | - |
dc.contributor.author | Lee, E | - |
dc.date.accessioned | 2024-05-14T06:49:54Z | - |
dc.date.available | 2024-05-14T06:49:54Z | - |
dc.date.created | 2024-04-15 | - |
dc.date.issued | 2005-08 | - |
dc.identifier.citation | The Journal of Organic Chemistry, Vol.70 No.16, pp.6321-6329 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201911 | - |
dc.description.abstract | (+)-SCH 351448 (Na+ salt A) was synthesized employing ring-closing olefin metathesis reaction of an open diene diester intermediate for construction of the 28-membered macrodiolide structure. The open diene diester was prepared from the monomeric hydroxy carboxylic acid and two different olefin fragments. The monomeric hydroxy acid was synthesized via Julia-Julia coupling reaction of intermediates derived from the same olefinic fragments. Oxane units in these fragments were prepared by radical cyclization reactions of beta-alkoxyacrylates. Analogous SCH 351448 salts incorporating other mono- and divalent cations may be prepared. Under acidic conditions, SCH 351448 (Na+ salt A) was the most stable complex, but SCH 351448 (Ca2+ salt) and (Na+ salt B) appear to be physiologically important species. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Stereoselective synthesis of (+)-SCH 351448: A unique ligand system for sodium, calcium, and other cations | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/jo0507993 | - |
dc.citation.journaltitle | The Journal of Organic Chemistry | - |
dc.identifier.wosid | 000230909100024 | - |
dc.identifier.scopusid | 2-s2.0-23044462557 | - |
dc.citation.endpage | 6329 | - |
dc.citation.number | 16 | - |
dc.citation.startpage | 6321 | - |
dc.citation.volume | 70 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chung, YK | - |
dc.contributor.affiliatedAuthor | Kim, JS | - |
dc.contributor.affiliatedAuthor | Kim, HJ | - |
dc.contributor.affiliatedAuthor | Lee, E | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CHIRAL SYNTHESIS | - |
dc.subject.keywordPlus | ORGANOBORANES | - |
dc.subject.keywordPlus | METABOLITE | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | ALDEHYDES | - |
dc.subject.keywordPlus | NUCLEUS | - |
dc.subject.keywordPlus | ACID | - |
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