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Asymmetric Phase-Transfer Catalytic aza-Michael Addition to Cyclic Enone: Highly Enantioselective and Diastereoselective Synthesis of Cyclic 1,3-Aminoalcohols
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jaeyong | - |
dc.contributor.author | Ban, Jeong Woo | - |
dc.contributor.author | Kim, Jeongseok | - |
dc.contributor.author | Yang, Sehun | - |
dc.contributor.author | Lee, Geumwoo | - |
dc.contributor.author | Dhorma, Lama Prema | - |
dc.contributor.author | Kim, Mi-hyun | - |
dc.contributor.author | Ha, Min Woo | - |
dc.contributor.author | Hong, Suckchang | - |
dc.contributor.author | Park, Hyeung-geun | - |
dc.date.accessioned | 2024-05-14T07:16:12Z | - |
dc.date.available | 2024-05-14T07:16:12Z | - |
dc.date.created | 2022-04-06 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.citation | Organic Letters, Vol.24 No.8, pp.1647-1651 | - |
dc.identifier.issn | 1523-7060 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201990 | - |
dc.description.abstract | The highly enantioselective aza-Michael reaction of tert-butyl beta-naphthylmetlioxycarbamate to cyclic enones has been accomplished by using a new cinchona alkaloid derived C(9)-urea ammonium catalyst under phase-transfer catalysis conditions with up to 98% ee at 0 degrees C. The resulting aza-Michael adducts can be converted to versatile intermediates by selective deprotection and the cyclic 1,3-aminoalcohols by diastereoselective reduction with up to 32:1, which have been widely used as important pharmacophores in pharmaceutical development. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Asymmetric Phase-Transfer Catalytic aza-Michael Addition to Cyclic Enone: Highly Enantioselective and Diastereoselective Synthesis of Cyclic 1,3-Aminoalcohols | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.orglett.2c00192 | - |
dc.citation.journaltitle | Organic Letters | - |
dc.identifier.wosid | 000766225300014 | - |
dc.identifier.scopusid | 2-s2.0-85125406170 | - |
dc.citation.endpage | 1651 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 1647 | - |
dc.citation.volume | 24 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hong, Suckchang | - |
dc.contributor.affiliatedAuthor | Park, Hyeung-geun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CONJUGATE ADDITION | - |
dc.subject.keywordPlus | SALT | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | AMINES | - |
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