Publications
Detailed Information
Unprecedented Noncanonical Features of the Nonlinear Nonribosomal Peptide Synthetase Assembly Line for WS9326A Biosynthesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Myoun-Su | - |
dc.contributor.author | Bae, Munhyung | - |
dc.contributor.author | Jung, Ye-Eun | - |
dc.contributor.author | Kim, Jung Min | - |
dc.contributor.author | Hwang, Sunghoon | - |
dc.contributor.author | Song, Myoung Chong | - |
dc.contributor.author | Ban, Yeon Hee | - |
dc.contributor.author | Bae, Eun Seo | - |
dc.contributor.author | Hong, Suckchang | - |
dc.contributor.author | Lee, Sang Kook | - |
dc.contributor.author | Cha, Sun-Shin | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.contributor.author | Yoon, Yeo Joon | - |
dc.date.accessioned | 2024-05-14T07:16:19Z | - |
dc.date.available | 2024-05-14T07:16:19Z | - |
dc.date.created | 2021-07-26 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | Angewandte Chemie - International Edition, Vol.60 No.36, pp.19766-19773 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | https://hdl.handle.net/10371/201992 | - |
dc.description.abstract | Systematic inactivation of nonribosomal peptide synthetase (NRPS) domains and translocation of the thioesterase (TE) domain revealed several unprecedented nonlinear NRPS assembly processes during the biosynthesis of the cyclodepsipeptide WS9326A in Streptomyces sp. SNM55. First, two sets of type Iota Iota TE (TE Iota Iota)-like enzymes mediate the shuttling of activated amino acids between two sets of stand-alone adenylation (A)-thiolation (T) didomain modules and an "A-less" condensation (C)-T module with distinctive specificities and flexibilities. This was confirmed by the elucidation of the affinities of the A-T didomains for the TE Iota Iota s and its structure. Second, the C-T didomain module operates iteratively and independently from other modules in the same protein to catalyze two chain elongation cycles. Third, this biosynthetic pathway includes the first example of module skipping, where the interpolated C and T domains are required for chain transfer. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Unprecedented Noncanonical Features of the Nonlinear Nonribosomal Peptide Synthetase Assembly Line for WS9326A Biosynthesis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/anie.202103872 | - |
dc.citation.journaltitle | Angewandte Chemie - International Edition | - |
dc.identifier.wosid | 000662131800001 | - |
dc.identifier.scopusid | 2-s2.0-85108086965 | - |
dc.citation.endpage | 19773 | - |
dc.citation.number | 36 | - |
dc.citation.startpage | 19766 | - |
dc.citation.volume | 60 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hong, Suckchang | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kook | - |
dc.contributor.affiliatedAuthor | Oh, Dong-Chan | - |
dc.contributor.affiliatedAuthor | Yoon, Yeo Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CARRIER PROTEIN DOMAINS | - |
dc.subject.keywordPlus | POLYKETIDE SYNTHASE | - |
dc.subject.keywordPlus | GENE-CLUSTER | - |
dc.subject.keywordPlus | PHOSPHOPANTETHEINYL TRANSFERASE | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | MODULE | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | ENZYMOLOGY | - |
dc.subject.keywordPlus | CATALYZES | - |
dc.subject.keywordAuthor | biosynthesis | - |
dc.subject.keywordAuthor | module iteration | - |
dc.subject.keywordAuthor | module skipping | - |
dc.subject.keywordAuthor | nonribosomal peptide synthetase | - |
dc.subject.keywordAuthor | shuttling thioesterase | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.