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Site-Selective C-H Amidation of 2-Aryl Quinazolinones Using Nitrene Surrogates
Cited 6 time in
Web of Science
Cited 6 time in Scopus
- Authors
- Issue Date
- 2020-12-13
- Publisher
- John Wiley & Sons Ltd.
- Citation
- European Journal of Organic Chemistry, Vol.2020 No.46, pp.7134-7143
- Abstract
- The site-selective modifications of quinazolinones constitute a pivotal topic in drug discovery and material science. Herein, we describe the rhodium(III)-catalyzed C-H amidation of 2-aryl quinazolin-4(3H)-ones with a range of nitrene surrogates including dioxazolones, organic azides, andN-methoxyamides. Complete site-selectivity and functional group tolerance are observed. Notably, the large-scale reaction and late-stage functionalization highlight the synthetic potential of the developed protocol. Combined mechanistic investigations elucidate a plausible reaction mechanism of this process.
- ISSN
- 1434-193X
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