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Synthesis of 2-aryl quinazolinonesviairon-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds

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dc.contributor.authorJang, Yoonkyung-
dc.contributor.authorLee, Seok Beom-
dc.contributor.authorHong, Junhwa-
dc.contributor.authorChun, Simin-
dc.contributor.authorLee, Jeeyeon-
dc.contributor.authorHong, Suckchang-
dc.date.accessioned2024-05-14T07:17:08Z-
dc.date.available2024-05-14T07:17:08Z-
dc.date.created2020-08-10-
dc.date.issued2020-07-
dc.identifier.citationOrganic and Biomolecular Chemistry, Vol.18 No.28, pp.5435-5441-
dc.identifier.issn1477-0520-
dc.identifier.urihttps://hdl.handle.net/10371/202005-
dc.description.abstractHerein, we describe the direct synthesis of quinazolinonesviacross-dehydrogenative coupling between methyl arenes and anthranilamides. The C-H functionalization of the benzylic sp(3)carbon is achieved by di-t-butyl peroxide under air, and the subsequent amination-aerobic oxidation process completes the annulation process. Iron catalyzed the whole reaction process and various kinds of functional groups were tolerated under the reaction conditions, providing 31 examples of 2-aryl quinazolinones using methyl arene derivatives in yields of 57-95%. The synthetic potential has been demonstrated by the additional synthesis of aryl-containing heterocycles.-
dc.language영어-
dc.publisherRoyal Society of Chemistry-
dc.titleSynthesis of 2-aryl quinazolinonesviairon-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds-
dc.typeArticle-
dc.identifier.doi10.1039/d0ob00866d-
dc.citation.journaltitleOrganic and Biomolecular Chemistry-
dc.identifier.wosid000550965600016-
dc.identifier.scopusid2-s2.0-85088492376-
dc.citation.endpage5441-
dc.citation.number28-
dc.citation.startpage5435-
dc.citation.volume18-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorLee, Jeeyeon-
dc.contributor.affiliatedAuthorHong, Suckchang-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusONE-POT SYNTHESIS-
dc.subject.keywordPlusOXIDATIVE SYNTHESIS-
dc.subject.keywordPlusO-AMINOBENZAMIDES-
dc.subject.keywordPlusAEROBIC OXIDATION-
dc.subject.keywordPlusBENZYL ALCOHOLS-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusMETAL-
dc.subject.keywordPlusINHIBITORS-
dc.subject.keywordPlusAMINATION-
dc.subject.keywordPlus2-AMINOBENZAMIDES-
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  • College of Pharmacy
  • Department of Manufacturing Pharmacy
Research Area Development of methodologies using metal catalyst, Total synthesis of natural products

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