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Total synthesis of swinholide A: An exposition in hydrogen-mediated C-C bond formation
Cited 44 time in
Web of Science
Cited 45 time in Scopus
- Authors
- Issue Date
- 2016-11
- Publisher
- American Chemical Society
- Citation
- Journal of the American Chemical Society, Vol.138 No.43, pp.14246-14249
- Abstract
- Diverse hydrogen-mediated C-C couplings enable construction of the actin-binding marine polyketide swinholide A in only 15 steps (longest linear sequence), roughly half the steps required in two prior total syntheses. The redox-economy, chemo- and stereoselectivity embodied by this new class of C-C couplings are shown to evoke a step-change in efficiency.
- ISSN
- 0002-7863
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Related Researcher
- College of Pharmacy
- Department of Manufacturing Pharmacy
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