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Phase-transfer catalyzed enantioselective α-alkylation of α-acyloxymalonates: construction of chiral α-hydroxy quaternary stereogenic centers : Phase-transfer catalyzed enantioselective alpha-alkylation of alpha-acyloxymalonates: construction of chiral alpha-hydroxy quaternary stereogenic centers
DC Field | Value | Language |
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dc.contributor.author | Ha, Min Woo | - |
dc.contributor.author | Choi, Sujee | - |
dc.contributor.author | Kim, Seek | - |
dc.contributor.author | Lee, Jun Young | - |
dc.contributor.author | Lee, Jae Kyun | - |
dc.contributor.author | Lee, Jeeyeon | - |
dc.contributor.author | Hong, Suckchang | - |
dc.contributor.author | Park, Hyeung-geun | - |
dc.date.accessioned | 2024-05-14T07:17:48Z | - |
dc.date.available | 2024-05-14T07:17:48Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | RSC Advances, Vol.6 No.81, pp.77427-77430 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202015 | - |
dc.description.abstract | The enantioselective synthesis of alpha-acyloxy-alpha-alkylmalonates was developed as an efficient method for producing chiral alpha-tertiary alcohols, which are potentially valuable intermediates in the synthesis of natural products and pharmaceuticals. The efficient enantioselective alpha-alkylation of diphenylmethyl tert-butyl alpha-acyloxymalonates was accomplished via phase-transfer catalysis in the presence of (S, S)-3,4,5-trifluorophenyl-NAS bromide to afford the corresponding alpha-acyloxy-alpha-alkylmalonates at high chemical (up to 99%) and optical (up to 93% ee) yields, which could be readily converted to versatile chiral intermediates with a chiral alpha-tertiary alcohol group. | - |
dc.language | 영어 | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | Phase-transfer catalyzed enantioselective α-alkylation of α-acyloxymalonates: construction of chiral α-hydroxy quaternary stereogenic centers | - |
dc.title.alternative | Phase-transfer catalyzed enantioselective alpha-alkylation of alpha-acyloxymalonates: construction of chiral alpha-hydroxy quaternary stereogenic centers | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/c6ra15121c | - |
dc.citation.journaltitle | RSC Advances | - |
dc.identifier.wosid | 000382482200034 | - |
dc.identifier.scopusid | 2-s2.0-85017440437 | - |
dc.citation.endpage | 77430 | - |
dc.citation.number | 81 | - |
dc.citation.startpage | 77427 | - |
dc.citation.volume | 6 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Jeeyeon | - |
dc.contributor.affiliatedAuthor | Hong, Suckchang | - |
dc.contributor.affiliatedAuthor | Park, Hyeung-geun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PIG-LIVER ESTERASE | - |
dc.subject.keywordPlus | BETA-KETO-ESTERS | - |
dc.subject.keywordPlus | ASYMMETRIC-SYNTHESIS | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | STEREOSELECTIVE-SYNTHESIS | - |
dc.subject.keywordPlus | ORGANIC-SYNTHESIS | - |
dc.subject.keywordPlus | ATOM-TRANSFER | - |
dc.subject.keywordPlus | AMINOXYLATION | - |
dc.subject.keywordPlus | (R)-BICALUTAMIDE | - |
dc.subject.keywordPlus | KETOESTERS | - |
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