Publications
Detailed Information
Enantioselective α-alkylation of benzylideneamino tert-butyl malonates by phase-transfer catalysis : Enantioselective alpha-alkylation of benzylideneamino tert-butyl Malonates by phase-transfer catalysis
Cited 10 time in
Web of Science
Cited 10 time in Scopus
- Authors
- Issue Date
- 2015-09
- Publisher
- John Wiley & Sons Ltd.
- Citation
- Advanced Synthesis and Catalysis, Vol.357 No.13, pp.2841-2848
- Abstract
- A new enantioselective synthetic method for the synthesis of alpha,alpha-dialkylmalonates with a quaternary carbon center was developed via alpha-alkylation of prochiral malonates by phase-transfer catalysis (PTC). Asymmetric alpha-alkylation of benzylideneamino tert-butyl alpha-methylmalonates under phase-transfer catalytic conditions in the presence of (S,S)-3,4,5-trifluorophenyl-NAS bromide afforded the corresponding alpha,alpha-dialkylmalonates in high yields (up to 97%) with excellent enantioselectivities (up to 98% ee). The products were then selectively hydrolyzed to chiral malonic monoacids under basic, acidic, or catalytic hydrogenation conditions.
- ISSN
- 1615-4150
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.