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Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents : Asymmetric synthesis and evaluation of alpha-quaternary chiral lactam derivatives as novel anticancer agents
DC Field | Value | Language |
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dc.contributor.author | Lee, Hwanhyuk | - |
dc.contributor.author | Hwang, Su Jung | - |
dc.contributor.author | Jung, Jisung | - |
dc.contributor.author | Hong, Suckchang | - |
dc.contributor.author | Lee, Myungmo | - |
dc.contributor.author | Park, Hyeung-geun | - |
dc.contributor.author | Lee, Hyo-Jong | - |
dc.contributor.author | Park, Yohan | - |
dc.date.accessioned | 2024-05-14T07:18:16Z | - |
dc.date.available | 2024-05-14T07:18:16Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.citation | Archives of Pharmacal Research, Vol.37 No.10, pp.1264-1270 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202022 | - |
dc.description.abstract | Asymmetric synthesis of alpha-quaternary chiral lactam derivatives as novel anticancer agents and evaluation of their cytotoxic potentials and spectrums are reported. Among the developed lactam derivatives, the most active new compounds (S)-4m and (S)-4n synthesized via asymmetric phase-transfer catalytic alkylation in very high optical yields (98 % ee) show promising in vitro anticancer activities with low micromolar IC50 values against colon, uterus, lung, and breast human cancer cells. | - |
dc.language | 영어 | - |
dc.publisher | 대한약학회 | - |
dc.title | Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents | - |
dc.title.alternative | Asymmetric synthesis and evaluation of alpha-quaternary chiral lactam derivatives as novel anticancer agents | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12272-013-0274-4 | - |
dc.citation.journaltitle | Archives of Pharmacal Research | - |
dc.identifier.wosid | 000342441800003 | - |
dc.identifier.scopusid | 2-s2.0-84938876526 | - |
dc.citation.endpage | 1270 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 1264 | - |
dc.citation.volume | 37 | - |
dc.identifier.kciid | ART001921284 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hong, Suckchang | - |
dc.contributor.affiliatedAuthor | Park, Hyeung-geun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PHASE-TRANSFER CATALYSIS | - |
dc.subject.keywordPlus | BETA-LACTAMS | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | ESTERS | - |
dc.subject.keywordPlus | 5-FLUOROURACIL | - |
dc.subject.keywordPlus | ALKYLATION | - |
dc.subject.keywordPlus | SUNITINIB | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordAuthor | alpha-Quaternary chiral lactam | - |
dc.subject.keywordAuthor | Phase-transfer catalytic alkylation | - |
dc.subject.keywordAuthor | Colon | - |
dc.subject.keywordAuthor | Lung | - |
dc.subject.keywordAuthor | Breast cancers | - |
dc.subject.keywordAuthor | Anticancer activity | - |
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