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N-methylthioureas as new agonists of retinoic acid receptor-related orphan receptor
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Park, Yohan | - |
| dc.contributor.author | Hong, Suckchang | - |
| dc.contributor.author | Lee, Myungmo | - |
| dc.contributor.author | Jung, Hyojun | - |
| dc.contributor.author | Cho, Won-Jea | - |
| dc.contributor.author | Kim, Eun-Jin | - |
| dc.contributor.author | Son, Ho-Young | - |
| dc.contributor.author | Lee, Mi-Ock | - |
| dc.contributor.author | Park, Hyeung-geun | - |
| dc.date.accessioned | 2024-05-14T07:18:44Z | - |
| dc.date.available | 2024-05-14T07:18:44Z | - |
| dc.date.created | 2017-11-15 | - |
| dc.date.issued | 2012-08 | - |
| dc.identifier.citation | Archives of Pharmacal Research, Vol.35 No.8, pp.1393-1401 | - |
| dc.identifier.issn | 0253-6269 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/202029 | - |
| dc.description.abstract | Thirty two thiourea derivatives were prepared and their agonistic activities on the retinoic acid receptor-related orphan receptor alpha (ROR alpha) were evaluated. The replacement of the 3-allyl-2-imino-thiazolidin-4-one moiety of the lead compound CGP52608 (1) with various functional group substituted aromatic rings, improved the agonistic activity of ROR alpha. Among the prepared derivatives, 1-methyl-3-(4-phenoxy-benzyl)-thiourea (32) showed 2.6-fold higher agonistic activity than CGP52608 in the ROR alpha-activation assay. | - |
| dc.language | 영어 | - |
| dc.publisher | 대한약학회 | - |
| dc.title | N-methylthioureas as new agonists of retinoic acid receptor-related orphan receptor | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.1007/s12272-012-0809-0 | - |
| dc.citation.journaltitle | Archives of Pharmacal Research | - |
| dc.identifier.wosid | 000308244800010 | - |
| dc.identifier.scopusid | 2-s2.0-84868096066 | - |
| dc.citation.endpage | 1401 | - |
| dc.citation.number | 8 | - |
| dc.citation.startpage | 1393 | - |
| dc.citation.volume | 35 | - |
| dc.identifier.kciid | ART001686333 | - |
| dc.description.isOpenAccess | N | - |
| dc.contributor.affiliatedAuthor | Hong, Suckchang | - |
| dc.contributor.affiliatedAuthor | Lee, Mi-Ock | - |
| dc.contributor.affiliatedAuthor | Park, Hyeung-geun | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.subject.keywordPlus | ROR-GAMMA-T | - |
| dc.subject.keywordPlus | NUCLEAR RECEPTOR | - |
| dc.subject.keywordPlus | GENE-EXPRESSION | - |
| dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVATION | - |
| dc.subject.keywordPlus | ALPHA | - |
| dc.subject.keywordPlus | LIGAND | - |
| dc.subject.keywordPlus | IDENTIFICATION | - |
| dc.subject.keywordPlus | CHOLESTEROL | - |
| dc.subject.keywordPlus | METABOLISM | - |
| dc.subject.keywordPlus | SUBFAMILY | - |
| dc.subject.keywordAuthor | Thiourea derivatives | - |
| dc.subject.keywordAuthor | Agonists | - |
| dc.subject.keywordAuthor | Retinoid acid receptor-related orphan receptor alpha | - |
| dc.subject.keywordAuthor | CGP52608 | - |
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- College of Pharmacy
- Department of Manufacturing Pharmacy
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