Publications

Detailed Information

Gold Nanoparticle-Carrying T Cells for the Combined Immuno-Photothermal Therapy

DC Field Value Language
dc.contributor.authorKim, HyeMi-
dc.contributor.authorBaek, Yujin-
dc.contributor.authorHa, Taeyong-
dc.contributor.authorChoi, Doowon-
dc.contributor.authorLee, Woo Jin-
dc.contributor.authorCho, Yongbum-
dc.contributor.authorPark, Jeehun-
dc.contributor.authorKim, Sungjee-
dc.contributor.authorDoh, Junsang-
dc.date.accessioned2024-05-16T01:19:28Z-
dc.date.available2024-05-16T01:19:28Z-
dc.date.created2023-08-07-
dc.date.created2023-08-07-
dc.date.issued2023-11-
dc.identifier.citationSmall, Vol.19 No.47-
dc.identifier.issn1613-6810-
dc.identifier.urihttps://hdl.handle.net/10371/202397-
dc.description.abstractCancer immunotherapy is a promising therapy to treat cancer patients with minimal toxicity, but only a small fraction of patients responded to it as a monotherapy. In this study, a strategy to boost therapeutic efficacy by combining an immunotherapy based on ex vivo expanded tumor-reactive T cells is devised, or adoptive cell therapy (ACT), with photothermal therapy (PTT). Smart gold nanoparticles (sAuNPs), which aggregates to form gold nanoclusters in the cells, are loaded into T cells, and their photothermal effects within T cells are confirmed. When transferred into tumor-bearing mice, large number of sAuNP-carrying T cells successfully infiltrate into tumor tissues and exert anti-tumor activity to suspend tumor growth, but over time tumor cells evade and regrow. Of note, & AP;20% of injected doses of sAuNPs are deposited in tumor tissues, suggesting T cells are an efficient nanoparticle tumor delivery vehicle. When T cells no longer control tumor growth, PTT is performed to further eliminate tumors. In this manner, ACT and PTT are temporally coupled, and the combined immuno-photothermal treatment demonstrated significantly greater therapeutic efficacy than the monotherapy.-
dc.language영어-
dc.publisherWiley - V C H Verlag GmbbH & Co.-
dc.titleGold Nanoparticle-Carrying T Cells for the Combined Immuno-Photothermal Therapy-
dc.typeArticle-
dc.identifier.doi10.1002/smll.202301377-
dc.citation.journaltitleSmall-
dc.identifier.wosid001035419500001-
dc.identifier.scopusid2-s2.0-85165603922-
dc.citation.number47-
dc.citation.volume19-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorDoh, Junsang-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordAuthoradoptive cell therapy-
dc.subject.keywordAuthorgold nanoparticles-
dc.subject.keywordAuthorphotothermal therapy-
dc.subject.keywordAuthorT cells-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Related Researcher

  • College of Engineering
  • Department of Materials Science & Engineering
Research Area Ex Vivo Models, Lymphocyte Biology, Smart Biomaterials

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share