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Formation of cellular close-ended tunneling nanotubes through mechanical deformation

Cited 13 time in Web of Science Cited 14 time in Scopus

Chang, Minhyeok; Lee, O-Chul; Bu, Gayun; Oh, Jaeho; Yunn, Na-Oh; Ryu, Sung Ho; Kwon, Hyung-Bae; Kolomeisky, Anatoly B.; Shim, Sang-Hee; Doh, Junsang; Jeon, Jae-Hyung; Lee, Jong-Bong

Issue Date
American Association for the Advancement of Science
Science Advances, Vol.8 No.13, p. eabj3995
Membrane nanotubes or tunneling nanotubes (TNTs) that connect cells have been recognized as a previously unidentified pathway for intercellular transport between distant cells. However, it is unknown how this delicate structure, which extends over tens of micrometers and remains robust for hours, is formed. Here, we found that a TNT develops from a double filopodial bridge (DFB) created by the physical contact of two filopodia through helical deformation of the DFB. The transition of a DFB to a close-ended TNT is most likely triggered by disruption of the adhesion of two filopodia by mechanical energy accumulated in a twisted DFB when one of the DFB ends is firmly attached through intercellular cadherin-cadherin interactions. These studies pinpoint the mechanistic questions about TNTs and elucidate a formation mechanism.
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  • College of Engineering
  • Department of Materials Science & Engineering
Research Area Ex Vivo Models, Lymphocyte Biology, Smart Biomaterials


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