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Formation of cellular close-ended tunneling nanotubes through mechanical deformation

Cited 13 time in Web of Science Cited 14 time in Scopus
Authors

Chang, Minhyeok; Lee, O-Chul; Bu, Gayun; Oh, Jaeho; Yunn, Na-Oh; Ryu, Sung Ho; Kwon, Hyung-Bae; Kolomeisky, Anatoly B.; Shim, Sang-Hee; Doh, Junsang; Jeon, Jae-Hyung; Lee, Jong-Bong

Issue Date
2022-04
Publisher
American Association for the Advancement of Science
Citation
Science Advances, Vol.8 No.13, p. eabj3995
Abstract
Membrane nanotubes or tunneling nanotubes (TNTs) that connect cells have been recognized as a previously unidentified pathway for intercellular transport between distant cells. However, it is unknown how this delicate structure, which extends over tens of micrometers and remains robust for hours, is formed. Here, we found that a TNT develops from a double filopodial bridge (DFB) created by the physical contact of two filopodia through helical deformation of the DFB. The transition of a DFB to a close-ended TNT is most likely triggered by disruption of the adhesion of two filopodia by mechanical energy accumulated in a twisted DFB when one of the DFB ends is firmly attached through intercellular cadherin-cadherin interactions. These studies pinpoint the mechanistic questions about TNTs and elucidate a formation mechanism.
ISSN
2375-2548
URI
https://hdl.handle.net/10371/202442
DOI
https://doi.org/10.1126/sciadv.abj3995
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  • Department of Materials Science & Engineering
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